National Health and Nutrition Examination Survey

2010-2010 Data Documentation, Codebook, and Frequencies

Influenza A (H3N2) Variant Virus & Historical Seasonal H3N2 Influenza Viruses Antibodies (Surplus) (SSIF_F_R)

RDC Only Data File: SSIF_F_R.xpt

First Published: January 2015

Last Revised: October 2015

Due to disclosure issues, this dataset is not available publicly. Access may be obtained through the NCHS Research Data Center (https://www.cdc.gov/rdc).

Component Description

Influenza serological testing of stored sera from NHA NES 2010 collection across various age groups, were used in this study to determine the population level of cross-reactive antibodies to H3N2v virus and historical seasonal H3N2 viruses. This data release contain the hemagglutination inhibition (HI) titers to H3N2v and historical seasonal H3N2 viruses.

Eligible Sample

A sample of participants across 9 age groups from stored NHANES 2010 sera. Ages 6+ No weights are provided with this file.

Description of Laboratory Methodology

Antibody titers against H3N2v and historical seasonal H3N2 influenza viruses were measured with hemagglutination inhibition (HI) assay at Influenza Division, Centers for Disease Control and Prevention.

The selected H3N2v viruses were: A/Indiana/17/2013, A/Indiana/6/2013, and A/Ohio/13/2012. The selected historical H3N2 viruses were: A/Aichi/2/1968, A/Victoria/3/1975, A/Bangkok/1/1979, A/Shanghai/11/1987, A/Beijing/32/1992, A/Wuhan/359/1995, A/Sydney/5/1997, A/Fujian/411/2002, and A/Brisbane/10/2007.

The geometric mean titers are reported. Although H3N2v has been circulating in the United States for a few years, a cut off value for seropositivity has not been determined.

Data Processing and Editing

Data was compiled after all the antibody testing was completed. The data were not edited.

Data Access: All data are publicly available.

Analytic Notes

There are twelve variables:

HI A/INDIANA/17/2013: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2v virus A/Indiana/17/2013.
Continuous variable - Values range from <10 (the limit of detection) to 10240

HI A/INDIANA/6/2013: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2v virus A/Indiana/06/2013.
Continuous variable - Values range from <10 (the limit of detection) to 10240

HI A/OHIO/13/2012: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2v virus A/Ohio/13/2012.
Continuous variable - Values range from <10 (the limit of detection) to 10240

HI A/AICHI/2/1968: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2 virus A/Aichi/2/1968.
Continuous variable - Values range from <10 (the limit of detection) to 10240

HI A/VICTORIA/3/1975: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2 virus A/Victoria/3/1975.
Continuous variable - Values range from <10 (the limit of detection) to 10240

HI A/BANGKOK/1/1979: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2 virus A/Bangkok/1/1979.
Continuous variable - Values range from <10 (the limit of detection) to 10240

HI A/SHANGHAI/11/1987: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2 virus A/Shanghai/11/1987.
Continuous variable - Values range from <10 (the limit of detection) to 10240

HI A/BEIJING/32/1992: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2 virus A/Beijing/32/1992.
Continuous variable - Values range from <10 (the limit of detection) to 10240

HI A/WUHAN/359/1995: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2 virus A/Wuhan/359/1995.
Continuous variable - Values range from <10 (the limit of detection) to 10240

HI A/SYDNEY/5/1997: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2 virus A/Sydney/5/1997.
Continuous variable - Values range from <10 (the limit of detection) to 10240

HI A/FUJIAN/411/2002: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2 virus A/Fujian/411/2002.
Continuous variable - Values range from <10 (the limit of detection) to 10240

HI A/BRISBANE/10/2007: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2 virus A/Brisbane/10/2007.
Continuous variable - Values range from <10 (the limit of detection) to 10240

The limit of detection has been changed to 5 on the data file for all variables.

References

Centers for Disease Control and Prevention. Detected U.S. Human infections with H3N2v by State since August 2011. 2013.
http://www.cdc.gov/flu/swineflu/h3n2v-case-count.htm
.
Centers for Disease Control and Prevention. First H3N2 Variant Virus Infection Reported for 2012. 2012.
http://whqlibdoc.who.int/publications/2011/9789241548090_eng.pdf
.
Centers for Disease Control and Prevention. Swine-origin influenza A (H3N2) virus infection in two children—Indiana and Pennsylvania, July-August 2011. MMWR Morb Mortal Wkly Rep, 2011. 60(35): p.1213-5.
.
Epperson, S., et al. Human infections with influenza A (H3N2) variant virus in the United States, 2011-2012. Clin Infect Dis, 2013. 57 Suppl 1: p.S4-S11.
.
World Health Organization. WHO global influenza surveillance network: Manual for the laboratory diagnosis and virological surveillance of influenza. 2011.
http://whqlibdoc.who.int/publications/2011/9789241548090_eng.pdf
.

Codebook and Frequencies

SEQN - Respondent sequence number

Variable Name:: SEQN
SAS Label:: Respondent sequence number
English Text:: Respondent sequence number.
Target:: Both males and females 6 YEARS - 150 YEARS

RIDAGEYR - Age in years at screening

Variable Name:: RIDAGEYR
SAS Label:: Age in years at screening
English Text:: Age in years at screening
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
6 to 102	Range of Values	1007	1007
.	Missing	0	1007

SSAIND17 - Influenza A/Indiana/17/2013 H3N2

Variable Name:: SSAIND17
SAS Label:: Influenza A/Indiana/17/2013 H3N2
English Text:: Influenza A/Indiana/17/2013 H3N2
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 1280	Range of Values	374	374
.	Missing	633	1007

SSAIND6 - Influenza A/Indiana/6/ 2013 H3N2

Variable Name:: SSAIND6
SAS Label:: Influenza A/Indiana/6/ 2013 H3N2
English Text:: Influenza A/Indiana/6/ 2013 H3N2
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 1280	Range of Values	1007	1007
.	Missing	0	1007

SSAOHI13 - Influenza A/ Ohio/12/2012 H32N2

Variable Name:: SSAOHI13
SAS Label:: Influenza A/ Ohio/12/2012 H32N2
English Text:: Influenza A/ Ohio/12/2012 H32N2
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 1280	Range of Values	1007	1007
.	Missing	0	1007

SSAAIC2 - Influenza A/Aichi/2/1968 H3N2

Variable Name:: SSAAIC2
SAS Label:: Influenza A/Aichi/2/1968 H3N2
English Text:: Influenza A/Aichi/2/1968 H3N2
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 640	Range of Values	394	394
.	Missing	613	1007

SSAVIC3 - Influenza A/Victoria/3/1975 H3N2

Variable Name:: SSAVIC3
SAS Label:: Influenza A/Victoria/3/1975 H3N2
English Text:: Influenza A/Victoria/3/1975 H3N2
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 80	Range of Values	394	394
.	Missing	613	1007

SSABAN1 - Influenza A/Bangkok/1/1979 H3N2

Variable Name:: SSABAN1
SAS Label:: Influenza A/Bangkok/1/1979 H3N2
English Text:: Influenza A/Bangkok/1/1979 H3N2
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 160	Range of Values	394	394
.	Missing	613	1007

SSASHA11 - Influenza A/Shanghai/11/1987 H3N2

Variable Name:: SSASHA11
SAS Label:: Influenza A/Shanghai/11/1987 H3N2
English Text:: Influenza A/Shanghai/11/1987 H3N2
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 320	Range of Values	578	578
.	Missing	429	1007

SSABEI3 - Influenza A/Beijing/3/2/1992 H3N2

Variable Name:: SSABEI3
SAS Label:: Influenza A/Beijing/3/2/1992 H3N2
English Text:: Influenza A/Beijing/3/2/1992 H3N2
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 640	Range of Values	578	578
.	Missing	429	1007

SSAWU359 - Influenza A/Wuhan/359/1995 H3N2

Variable Name:: SSAWU359
SAS Label:: Influenza A/Wuhan/359/1995 H3N2
English Text:: Influenza A/Wuhan/359/1995 H3N2
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 1280	Range of Values	578	578
.	Missing	429	1007

SSASYD5 - Influenza A/Sydney 5/1997 H3N2

Variable Name:: SSASYD5
SAS Label:: Influenza A/Sydney 5/1997 H3N2
English Text:: Influenza A/Sydney 5/1997 H3N2
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 1280	Range of Values	578	578
.	Missing	429	1007

SSAFUJ4 - Influenza A/Fujian/4/11/2002 H3N2

Variable Name:: SSAFUJ4
SAS Label:: Influenza A/Fujian/4/11/2002 H3N2
English Text:: Influenza A/Fujian/4/11/2002 H3N2
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 2560	Range of Values	499	499
.	Missing	508	1007

SSABRI10 - Influenza A/Brisbane/10/2007 H3N2

Variable Name:: SSABRI10
SAS Label:: Influenza A/Brisbane/10/2007 H3N2
English Text:: Influenza A/Brisbane/10/2007 H3N2
Target:: Both males and females 6 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 2560	Range of Values	576	576
.	Missing	431	1007

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