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RM Materials - Material Availability

The purpose of the Genetic Testing Reference Materials Coordination Program (GeT-RM) is to help the genetic testing community obtain appropriate and characterized reference materials. This page has links to tables containing information on reference materials characterized by the GeT-RM program and a previous CDC project. These materials have been tested in several independent laboratories using a variety of test methods. New materials will be added to these tables as they are characterized.

We have also included tables listing information on available cell lines and other materials for selected disorders. Not all of the materials listed in these tables have been characterized by the GeT-RM program. Some of the listed materials have only been assayed by the submitter to the repository. Others have been further characterized by researchers, clinical laboratories or commercial manufacturers. Information on the characterization status of each material is shown. As the GeT-RM program proceeds, we will be updating the status of listed materials and adding information on materials available for other disorders.


Available materials for selected disorders

  • Pharmacogenetics
    • VKORC1 - All cell lines in this table have been characterized using various methods (including sequencing and Real Time PCR) by sources other than the GeT-RM.
    • VKORC1 and CYP2C9 - All cell lines in this table have been characterized using sequencing by sources other than the GeT-RM.
    • UGT1A1 - All cell lines in this table have been characterized using various methods (including Third Wave Technologies Invader® technology and sequencing) by sources other than the GeT-RM.
    • CYP2D6 - All cell lines in this table have been characterized using various methods (including Roche AmpliChip® and Luminex Tag-It® technologies, RFLP-PCR, and various home-brew assays) by sources other than the GeT-RM.
    • CYP2C9 - All cell lines in this table have been characterized using various methods (including Luminex Tag-It® technology and Real Time PCR) by sources other than the GeT-RM.
    • CYP2C19 - All cell lines in this table have been characterized using various methods (including Roche AmpliChip® and Luminex Tag-It® technologies, RFLP and sequencing) by sources other than the GeT-RM.
    • CYP2D6 and/or CYP2C9 and/or CYP2C19
  • Biochemical Genetics
    • Biochemical reference materials used in the ERNDIM (European Research Network for evaluation and improvement screening, Diagnosis and treatment of Inherited disorders of Metabolism) External Quality Assessment are available from the Control Materials section of the ERNDIM website.

  • Synthetic Controls Materials

  • Disclaimer:The CDC is not responsible for the validity of mutations in cell lines or any other materials. Inclusion of commercially available materials or reagents on this website does not constitute an endorsement of such materials by the CDC and no endorsement shall be stated or inferred.
     
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