The Centers for Medicare & Medicaid Services (CMS) and CDC are collaborating to update the CLIA proficiency testing (PT) requirements for laboratories and PT programs. As part of this, on March 10th and 11th, 2010, CDC hosted a meeting of a Clinical Laboratory Improvement Advisory Committee (CLIAC) workgroup to provide input to the federal advisory committee regarding necessary PT changes. The workgroup was co-chaired by Drs. James Nichols and Gerri Hall and included representatives of laboratories, PT programs, and laboratory surveyors. In addition, ex-officio members, Dr. Roberta Carey (CDC), Ms. Judith Yost (CMS), and Dr. Alberto Gutierrez (FDA), participated on behalf of the CLIA program. The workgroup concluded their deliberations via several teleconferences and will present their report to CLIAC at the September 2010 meeting.