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Michael Laposata, MD, PhD

Dr. Laposata is the Director of Clinical Laboratories and a physician in the Department of Medicine at the Massachusetts General Hospital (MGH) in Boston and a Professor of Pathology at Harvard Medical School since 1989. He received his MD and PhD from Johns Hopkins University School of Medicine and completed a postdoctoral research fellowship and residency in Laboratory Medicine at Washington University School of Medicine in St. Louis. He took his first faculty position at the University of Pennsylvania School of Medicine in Philadelphia in 1985, where he was an Assistant Professor and director of the hospital's coagulation laboratory.

His research program, with more than 100 peer-reviewed publications, has focused on fatty acids and their metabolites. His research group is focused on the study of fatty acids ethyl esters, which are esterification products of fatty acid and ethanol. He has demonstrated that these ethanol metabolites are toxic mediators of ethanol-induced cell injury and that the ethyl esters are present in the serum after ethanol intake, serving as long-term markers of ethanol intakes.

Dr. Laposata's clinical expertise is in the field of blood coagulation, with a special expertise in the diagnosis of hypercoagulable states.

He has implemented a system at MGH whereby the clinical laboratory data in coagulation, toxicology, and other areas are systematically interpreted with the generation of a patient-specific-narrative paragraph by a physician with expertise in the area. This service is essentially identical to the service provided by physicians in radiology and anatomic pathology, except that it involves clinical laboratory test results.