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Meningococcal disease (Neisseria meningitidis) 
2010 Case Definition

CSTE Position Statement(s)

  • 09-ID-42

Case Classification

Suspected

  • Clinical purpura fulminans in the absence of a positive blood culture; OR
  • Gram-negative diplococci, not yet identified, isolated from a normally sterile body site (e.g., blood or cerebrospinal fluid [CSF]).

Probable

  • Detection of N. meningitidis-specific nucleic acid in a specimen obtained from a normally sterile body site (e.g.,. blood or CSF), using a validated polymerase chain reaction (PCR) assay, OR
  • Detection of N. meningitidis antigen:
    • in formalin-fixed tissue by immunohistochemistry (IHC); OR
    • in CSF by latex agglutination.

Confirmed

  • Isolation of Neisseria meningitidis:
    • From a normally sterile body site (e.g., blood or cerebrospinal fluid, or, less commonly, synovial, pleural, or pericardial fluid), OR
    • From purpuric lesions.

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