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AR Bank # 0832 Citrobacter freundii

Biosample Accession #: Biosample Accession data is not yet available.


Panel:  Plazomicin

MIC (μg/ml) Results and Interpretation
Drug MIC (μg/ml) INT
Amikacin 8S
Ampicillin >32R
Ampicillin/sulbactam 1>32R
Aztreonam <=2S
Cefazolin >8R
Cefepime 16R
Cefotaxime 16R
Cefotaxime/clavulanic acid 116---
Cefoxitin >16R
Ceftazidime 2S
Ceftazidime/avibactam 11S
Ceftazidime/clavulanic acid 12---
Ceftolozane/tazobactam 12S
Ceftriaxone 4R
Ciprofloxacin >8R
Colistin 0.5---
Doripenem 2I
Ertapenem 8R
Gentamicin >16R
Imipenem 4R
Imipenem+chelators 22---
Levofloxacin >8R
Meropenem 4R
Piperacillin/tazobactam 1>128R
Plazomicin 30.12S
Tetracycline >32R
Tigecycline 32S
Tobramycin >16R
Trimethoprim/sulfamethoxazole 1>8R
S – I –R Interpretation (INT) derived from CLSI 2018 M100 S28
Clinical and PK/PD data demonstrate colistin has limited clinical efficacy, even if an intermediate result is obtained. Alternative agents are strongly preferred. Colistin should be used in combination with one or more active antimicrobial agents. Consultation with an infectious disease specialist is recommended.

1 Reflects MIC of first component
2 Screen for metallo-beta-lactamase production [Rasheed et al. Emerging Infectious Diseases. 2013. 19(6):870-878]
3 Based on FDA break points
Molecular Mechanism of Resistance
The resistance mechanisms listed were identified by analysis of whole genome sequence using the ResFinder database (last updated June 2, 2016 and accessed on October 25, 2016). This analysis does not include mutations that may result in antibiotic resistance or resistance determinants added to newer versions of the ResFinder database or other antimicrobial resistance gene databases. Biosample accession numbers have been provided so that users can analyze the data on their own if so desired.
Medium: Trypticase Soy Agar with 5% Sheep Blood (BAP)

Temperature: 35°C
Atmosphere: Aerobic


Remove the sample vial to a container with dry ice or a freezer block. Keep vial on ice or block. (Do not let vial content thaw)

Open vial aseptically to avoid contamination

Using a sterile loop, remove a small amount of frozen isolate from the top of the vial

Aseptically transfer the loop to BAP

Use streak plate method to isolate single colonies

Incubate inverted plate at 35°C for 18-24 hrs.

Storage Temperature & Biosafety

Appropriate safety procedures should always be used with this material. Laboratory safety is discussed in the current publication of the BioSafety in Microbiological and Biomedical Laboratories (HHS Publication No. (CDC) 21-1112) from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, and National Institutes of Health.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. All materials are the property of the Centers for Disease Control and Prevention (CDC) and have been made available on behalf of the Food and Drug Administration (FDA). This material is not for use in human subjects and may not be redistributed. While CDC uses reasonable efforts to include accurate and up-to-date information on this product sheet, CDC makes no warranties or representations as to its accuracy. CDC is not liable for damages arising from the misidentification or misrepresentation of cultures. Please refer to the Standard Letter Agreement (SLA) for further details regarding the use of this product.
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