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Virus Name:
Hanzalova
Abbreviation:
HANV
Status
Arbovirus
Select Agent
No
SALS Level
4
SALS Basis
Placed in Level 4 based on the close antigenic relationship with a known Level 4 agent, Russian spring-summer encephalitis, plus insufficient laboratory experience.
Other Information
Vaccination Recommended
Antigenic Group
B
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
By CF and neutralization tests the virus is related to Russian Spring-Summer encephalitis virus and to louping ill virus.
Editor's Note: The Hanzalova strain is being registered because it appears to have been the first tick-borne encephalitis strain isolated in Czechoslovakia. Though it was not included in the studies of Clarke [5] , [6] , it presumably possesses the same antigenic characteristics as the Stillerova strain designated by Clarke as the prototype for the "Central European" serotype strains. According to Dr. Rampas the Stillerova strain was isolated from the blood of a laboratory assistant (Stillerova) who had a "mild abortive" infection while working with the Hanzalova or other strains which had been isolated.
Dr. Rampas states that "neither the Hanzalova nor the Stillerova strain has been published in any special report. Reference [1] describes the laboratory infection of Dr. Gallia himself. He fell ill about one month following inoculation of the Hanzalova material. The virus isolated from his blood was identical with the Hanzalova strain."
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