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  Hypr   HYPRV

Arbovirus

No

4

Results of SALS surveys and information from the Catalogue.
Other Information
Vaccination Recommended 

B
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
I. Neutralizing indices of immune hamster sera in cross-neutralization tests in mice (intraperitoneal inoculation):
 
Serum
Virus Hypr RSSE (Sofin) Absettarov Louping ill


* In thousands
Hypr 158.5 * 158.5 158.5 158.5
RSSE (Sofin) 67.6 67.6 67.6 67.6
Absettarov 1,600 1,600 1,600 1,600
Louping ill 1,400 1,400 1,400 1,400
II. Cross-complement fixation tests with immune hamster sera:
 
Serum
Antigen Hypr RSSE (Sofin) Absettarov Louping ill


** Serum of titers
Hypr 32 ** 8 8 16
RSSE (Sofin) 16 16 8 8
Absettarov 32 32 16 16
Louping ill 16 32 4 16
I. and II. See Reference [4] .
III. Neutralization tests with immune horse gamma globulin (1:1000) against the strain Hypr [5] in HeLa cells:
 
Neutralizing titers with viruses


Hypr 512 Absettarov 512
RSSE (Sofin) 512 OMSK 1024
Kyasanur Forest dis 512
IV. Negative results:
 


a) Cross-neutralization tests in mice with WEE, EEE and Theiler FA viruses
b) Cross-CF tests with SLE, Jap. B, EMC, LCM and FA viruses
 
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