| |
| Related to Icoaraci (Phlebotomus fever group) by HI: |
| |
| | Antigen (8 units) |
|---|
| Mouse hyperimmune Serum | Itaporanga | Icoaraci |
|---|
|
| | Itaporanga | 320 | <20 | | Icoaraci | 160 | 320 |
|
| Whitman (personal communication) reports Itaporanga related by HI to Naples sandfly fever virus. |
| Itaporanga hemagglutinin was not inhibited by hyperimmune sera for arboviruses of groups A, B, C, Bunyamwera and Guama plus 46 other arboviruses either ungrouped or in groups not yet recognized in formal publications; Sicilian sandfly fever virus serum is included in this list. Itaporanga serum (homologous titer = 320) did not inhibit hemagglutination of antigens for arbovirus groups A, B, C, and Guama. |
| A CF antigen for Itaporanga virus did not react with hyperimmune sera for arboviruses of groups A, B, C, Bunyamwera or Guama or for nine other arboviruses, including Icoaraci. Itaporanga serum (homologous titer = 64) did not fix complement with antigens for Bunyamwera group virus, seven other arboviruses including Icoaraci, or mouse encephalomyelitis virus. |
| In neutralization testing, the homologous hyperimmune mouse serum neutralized 2.4 dex LD50 of Itaporanga virus, but no significant neutralization by Icoaraci serum (homologous neutralizing index 2.8 dex LD50) was demonstrated. Conversely, Itaporanga serum failed to neutralize Icoaraci virus. |
| More recent serological studies indicate that Itaporanga virus is distinct by NT from other members of the PHL serogroup [9] , [10] . |
| |
