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  Macaua   MCAV

Probable Arbovirus

No

3

Isufficient experience with virus; i.e., experience factor from SALS surveys was less than 500 in laboratory facilities with low biocontainment.
Other Information
 

Bunyamwera
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
CF tests performed in Belem showed that Macaua virus shares an antigenic relationship with viruses of the Bunyamwera group.
 
Complement-Fixation Test
Sera
Antigens Macaua Iaco BeAr 328208 Tucunduba MAG KRI GRO SOR


b Serum titer/antigen titer; 0 = <4/<4
Macaua 256/>256 b 16/>=256 0 0 0 0 0 16/>256
Iaco 8/>=256 >=256/>=256
BeAr 328208 8/32 64/64
Tucunduba 16/>=256 64/>=256
Maguari 0 >=32/>=40
Kairi 0 16/>=64
Guaroa 0 >=32/>=40
Sororoca 8/64 256/>=256
 
PRNT in Vero cells [1]
Sera
Virus Macaua Iaco BeAr 328208 Tucunduba Taiassui SOR BAT NOR AMB BUN BIR SHO


c Reciprocal of highest dilution giving 80% plaque reduction
Macaua 128 c 8 <8 <8 16 <8 <8 8 8 <8 8 <8
Iaco 8 2048
BeAr 328208 16 128
Tucunduba 64
Taiassui 16 512
Sororoca 64-128
At YARU, Macaua CF antigen did not react with hyperimmune sera of Germiston, Ilesha, Lokern, Main Drain, Tensaw, Tlacotalpan and Playas viruses. Antigenic relationship was demonstrated with Batai, Northway, Anhembi, Bunyamwera, Santa Rosa, Birao, and Shokwe viruses. Sera of these viruses did not neutralize Macaua virus by PRNT in Vero cell cultures [1] .
 
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