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Virus Name: Machupo

Abbreviation: MACV

Status
Not Arbovirus

Select Agent
Yes

SALS Level
4

SALS Basis
Results of SALS surveys and information from the Catalogue.

Other Information
DOC Permit Required

Antigenic Group
Tacaribe

Section VIII - Susceptibility to Experimental Infection (include viremia)

Experimental host and age	Passage history and strain	Inoculation Route-Dose	Evidence of infection	AST (days)	Titer log10/ml


Mice (nb)	Carvallo SHB 2	ic 0.02	Neurological illness, death	16	6.7
Mice (nb)		ip 0.03	Neurological illness	17	3.7
Mice (nb)		sc
Mice (wn)		ic
Mice (wn)		ip
mice (5-6 day)		ic,ip 0.02	CF antibodies		4.5
hamster (nb)		ic,ip 0.02	Neurological illness, death	12-14	6.9
hamster (5-6 wk)		ic 0.2	CF antibodies, virus excretion in urine		6.5
Calomys callosus (infant)			Chronic viremia, immune tolerance (6)
Geoffrey's marmoset (ad)		sc 0.2	Non-specific illness, death(5)	12-15	6.2
cat (ad)	Carvallo SHB 3	sc 0.2	No illness
chicken (1-3 day)		sc 0.2	No illness
horse (ad)		sc 0.2	No illness
pig (ad)		sc 0.2	No illness; CF antibody prod.
rhesus monkeys (ad)	SHB 3	sc 0.5	Viremia and death(11)	14.3-19.5

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