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| | 1. | HI. In the HI test, MML hyperimmune mouse serum inhibited Ilheus, St. Louis (Parton) and Powassan (791-A) of group B in low dilution only, but did not inhibit group A antigens WEE and EEE. No others tested. | | 2. | CF | | Antiserum | Antigen | | | a. | Reaction | MML | Ilheus | | | | No reaction | MML | WEE | | | | No reaction | MML | Turlock | | | | Reaction | MML | ENT | | | | Reaction | MML | St. Louis | | | | No reaction | Ilheus | MML | | | | No reaction | Turlock | | | | No reaction | Trivittatus | | | | No reaction | Powassan | | | | No reaction | Tacaribe | | | | No reaction | EBSG | | | | No reaction | Modoc | | | Sera that did not react at 1:4 dilution in CF test with 1:16 dilution (1 unit) of MML antigen are as follows: Anopheles A, Anopheles B, Rio Bravo (Burns bat), bluetongue, Bunyamwera, Bwamba, California encephalitis, chikungunya, Colorado tick fever (Florio), Culiseta inornata, Cache Valley, dengue 1, dengue 2, dengue 4, EEE, o'nyong-nyong, Herpes, Ilheus, Itaqui, normal mouse, Microtus KF 11, Microtus KF 23, LCM, Mayaro, mouse polio GD 7, Ntaya, Quaranfil, RSSE, Sandfly fever, Semliki Forest, Sindbis, Chenuda, Nyamanini (Ar 1304), Uganda S, WEE, HJ, West Nile, YF 17D, Wyeomyia, Zika. | | 3. | Serum neut. tests. Ilheus, Powassan, ENT sera neutralized only small amount of MML virus. Reverse reaction did not occur. | | | Antisera vs. fixed rabies (PV-1), Rio Bravo, LCM and 2 strains of mouse poliovirus did not neutralize MML virus. | | | Two separate cross-neutralization studies, involving 42 and 65 flaviviruses respectively, have shown that MML virus is not closely related to any of the other flaviviruses, and thus cannot be placed in a complex or subgroup [5] , [6] . |
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