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  Ndumu   NDUV

Probable Arbovirus

No

3

Disease is sheep, cattle, or horses.
Other Information
 

A
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
 
NDU Antigen [2] NDU HIAF [2]
HIAF CF Antigens CF


Results expressed as quotient of Ho/Ht titers
Chikungunya >128 Chikungunya >32
Middelburg 32 Middelburg 32
Semliki Forest >1024 Semliki Forest >32
Sindbis >512 Sindbis >32
In cross PRNT, NDU virus was neutralized to a titer of 15 by a Whataroa antiserum (Ho titer = 100) but no reactions either way were obtained with WEE, Sindbis, Aura, VEE, Mucambo, Pixuna, Semliki Forest, Mayaro, chikungunya, Una, o'nyong nyong, Bebaru, Getah, Ross River, EEE, and Middelburg [3] .
In cross-neutralization tests in micro-cell culture NDU virus was neutralized by Aura antiserum Ho LNI (dex)/Ht LNI (dex) = 6.0/1.2) but not by antisera of 20 other group A viruses. NDU antiserum neutralized WEE virus (4.3/1.0) but none of the viruses [4] .
Placed in WEE serological subgroup as a distantly related member [5] . SIRACA has not placed NDU virus in the WEE complex. The virus is considered to be a distinct type which is not closely related to any other group A arbovirus; and thus has been placed in the Ndumu complex [12] .
 
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