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Virus Name: Oriximina

Abbreviation: ORXV

Status
Possible Arbovirus

Select Agent
No

SALS Level
3

SALS Basis
Isufficient experience with virus; i.e., experience factor from SALS surveys was less than 500 in laboratory facilities with low biocontainment.

Other Information

Antigenic Group
Phlebotomus fever

Section V - Antigenic Relationship and Lack of Relationship to Other Viruses

A CF relationship was demonstrated between BeAr 385309 and four other Phlebotomus fever group agents as noted below:

Complement-Fixation Test
	Sera
Antigens	BeAr 385309	ICO	BUJ	ITP	URU	CDU	ITA	ALE	TUA	PAC	ANH


^a Serum titer/antigen titer; 0 = <4/<4
BeAr 385309	64/>=64 ^a	0	0	0	0	>=128/>=64	>=128/>=64	8/>=64	32/>=64	0	0
Icoaraci	0	>=128/>=64
Bujaru	0		32/>=64
Itaporanga	0			>=16/>=64
Urucuri	0				>=128/>=64
Candiru	16/>=64					>=128/>=64
Itaituba	8/8						>=128/>=64
Alenquer	0							64/>=64
Turuna	0								>=128/>=64
Pacui	0									>=128/>=64
Anhanga	0										32/>=64

Results of NT showed that this virus is readily distinguishable from Candiru, Itaituba, Alenquer, and Turuna viruses.

Neutralization Test (Newborn Mice, ic)
	Sera
Viruses	BeAr 385309	ICO	BUJ	ITP	URU	CDU	ITA	ALE	TUA	PAC	ANH


^b LNI in dex
BeAr 385309	2.4 ^b	0.0	0.0	0.0	1.1	0.1	0.9	0.6	0.6	0.0	<=0.3
Candiru	0.1					3.5
Itaituba	0.7						>=5.0
Alenquer								2.7
Turuna	0.0								2.1

The CF results were confirmed at YARU and it was shown that this virus was ot related to Aguacate, Arumowot, Buenaventura, Cacao, Chilibre, Caimito, Chagres, Frijoles, Gabek Forest, Gordil, Karimabad, Naples, Rift Valley fever (serum only), Rio Grande, Saint-Floris, Salehabad, Sicilian, Teheran, and Toscana viruses. It was related to Nique and Punta Toro viruses by CF but differed by PRNT from Turuna, Nique, Itaporanga, Candiru and Punta Toro viruses.

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