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  Powassan   POWV

Arbovirus

No

3

Results of SALS surveys and information from the Catalogue.
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B
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
McLean and Donohue [1]
 
Antigen of Powassan virus Immune serum of Powassan virus
Immune sera (guinea pigs) 2 to 4 injs. HI CF NT Antigens HI CF NT


* Heterologous/homologous
NT: serum dilution plaque-reduction neutralization titers
Powassan 640 160 100+ Powassan 640 160 100+
St. Louis 320/ND *0/160 *0/400 * St. Louis 0/160 0/400
Murray Valley 40/ND 0/160 0/1000 Murray Valley 0/160 0/1000
Eastern equine 0/160 0/320 0/100+ Eastern equine 0/320 0/100
Western equine 0/ND 0/20 0/100 Western equine 0/20 0/100
Casals [2]
 
Antigen of Powassan virus Immune serum of Powassan virus
Immune sera (mice) several injs HI CF NT Antigens HI CF NT


* Heterologous/homologous
NT: serum dilution plaque-reduction neutralization titers.
Powassan 320 128 1000 Powassan 320 128 1000
RSSE 160/5120 *128/512 *110/300 * RSSE 160/5120 32/512 60/300
St. Louis 40/10240 0/512 8/1000 St. Louis 20/10240 4/512 30/1000
Rio Bravo 40/5120+ Rio Bravo 0/5120+
Ilheus 40/5120+ Ilheus 0/5120
Dengue 2 20/2560 Dengue 2 0/2560
Modoc 40/5120+
JBE 40/5120+
Bussuquara 0/320
Banzi 0/2560
In two separate cross-neutralization studies, one involving 42 flaviviruses, Powassan virus could not be placed in a complex [35] ; while the second study concerned 65 flaviviruses and placed Powassan in a complex consisting of 13 other primarily tick-borne flaviviruses [36] .
 
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