| | | See References [1] , [2] , and [3] . | | | | | Rio Bravo Antigen | | Rio Bravo Immune Serum |
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| Immune sera | HI | CF | NT | Antigen | HI | CF | NT |
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| | NT: LNI in dex | | Powassan | 0/320 | | | Powassan | 40/5120 | | | RSSE | 1280/5120 | 0/128 | | RSSE | 320/5120 | 16/128 | | SLE | 1280/10240 | | | SLE | 2560/5120 | | | Ilheus | 640/5120 | | | | | | | Modoc | 1280/5120 | 16/256 | <0.5/>6.0 | Modoc | 320/5120 | 0/16 | <0.5/>2.0 | | Bussuquara | 40/320 | | | | | |
| | Identified as same virus as that isolated in Texas by Dr. J.V. Irons [5] , Dr. K.F. Burns [4] , and in California by Dr. J.B. Enright [6] by NT at one or the other laboratory [3] . | | Cross immunity tests: not related to SLE, WE, California, CTF, LCM, and Powassan viruses. One way cross with Modoc virus, i.e., Modoc immunized mice resist challenge ic one month later with Rio Bravo virus; Rio Bravo immunized mice do not resist challenge ic one month later with Modoc virus [3] . | | Rio Bravo virus was determined to be antigenically distinct and cross- reacted minimally with other flaviviruses with undetermined arthropod-borne status [23] . | | |
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