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  Semliki Forest   SFV

Arbovirus

No

3

Fatal human laboratoryinfection, 1978, probably aerosol. This is recognized to be a unique incident in a long history of work with SFV under minimal biocontainment conditions. However, since the virulence characteristics of the strain responsible in this case require further study and the prevalence of subclinical infections in laboratories working with SFV remains unknown, the committee recommends Level 3 until further information is available warranting reconsideration at a lower level.
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A
Remarks
Prototype strain is in American Type Culture Collection. Two other rhesus monkeys became immune to Semliki after inoculation with wild-caught mosquitoes in Uganda, but no virus was isolated. * It is quite possible that positive sero reactors may be due to infection with other Group A viruses. Editor.
 
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