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  Semliki Forest   SFV

Arbovirus

No

3

Fatal human laboratoryinfection, 1978, probably aerosol. This is recognized to be a unique incident in a long history of work with SFV under minimal biocontainment conditions. However, since the virulence characteristics of the strain responsible in this case require further study and the prevalence of subclinical infections in laboratories working with SFV remains unknown, the committee recommends Level 3 until further information is available warranting reconsideration at a lower level.
Other Information
 

A
Section VII - Natural Host Range (Additional text can be added below table)
 
 
Vertebrate (species and organ) and arthropod No. isolations/No. tested No. with antibody/No. tested Test used Country and region


Mosquito isolations: 1 Aedes (Aedimorphus) abnormalis, Uganda(1); see Remarks.. 1 Ae (Adm) argenteopunctatus, Mozambique (16). 1 Eretmapodites grahami , Cameroun (5,32).1Ae palpalpis group, Central African Republic (34). 1 Ae (Adm) dentatus, Central plateau Kenya (39). 1 An (Cel) funestus, North Kenya (39). Aedes vittatus, Senegal (46).
Man Antibodies: By NT, Africa up to 46% (3,8,9,29), India 3/192 (30); Malaya, Borneo up to 37% (11,18); N. Vietnam, Thailand up to 34% (18); Philippines 18/119. By HI, Gambia 30/49 (31).
Aedes vexans 1 USSR, far east, 1971 (40)
Culex pipiens 1 USSR, far east, 1973 (40)
Sentinel mice 5 Nigeria (30)
Chimpanzee up to 38% NT Congo (Leo)
Wild birds 1 Central African Republic (34)
Quelea erythrops; wild birds; 1 2 CF, 1 HI Nigeria (38); Yugoslavia (19)
Atelerix albiventris 1 Nigeria (38)
Rodents 12/245 HI S. Africa
Domestic animals 13/386 NT
Man (CSF, brain) 1 W. Germany (41, 42)
 
 
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