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  Semliki Forest   SFV

Arbovirus

No

3

Fatal human laboratoryinfection, 1978, probably aerosol. This is recognized to be a unique incident in a long history of work with SFV under minimal biocontainment conditions. However, since the virulence characteristics of the strain responsible in this case require further study and the prevalence of subclinical infections in laboratories working with SFV remains unknown, the committee recommends Level 3 until further information is available warranting reconsideration at a lower level.
Other Information
 

A
Section VIII - Susceptibility to Experimental Infection (include viremia)
 
 
Experimental host and age Passage history and strain Inoculation Route-Dose Evidence of infection AST (days) Titer log10/ml


Rats born of immune mothers show immune tolerance (23).
Mice (nb) P-9 ic 0.02 Viremia, death 2 12.0
Mice (nb) ip
Mice (nb) sc
Mice (wn) P-4 ic 0.03 Death (1) 3-4 7.3
Mice (wn) ip 0.5 None at 10-2
Mice (5-6 wk) P-55 ic,ip,in Death (1) 3-6 6.7+
rabbits, gp(yg) P-19 ic,sc Fever (ic), antibody (1)
rabbits, gp High passage ic 0.1 Fever, paralysis, death (1)
hamsters ic, ip Fatal ic, ip variable. Can infect progeny through milk
rhesus monkeys High passage ic Fever, paralysis, death (1)
wild monkeys ic Sickness in most, usually followed by recovery and antibody
wild monkeys sc No sign of infection, usually antibody (1)
chick embryo (6-12 day) High passage various Death; 11-24 hrs (12,28)
chickens ic,im Viremia and antibody in some (32)
wild birds Viremia (33)
 
 
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