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| Results to follow should be interpreted with caution for the following reasons: |
| 1) Of the common laboratory animals inoculated with 69V-2161 virus, only rabbits produced PRNT antibodies of sufficient titer to be measurable in the duck embryo cell culture system. Supposedly immune serum from mice, chickens, and hamsters only minimumly neutralized the virus (LNI-0.5 to 0.9 dex) even though the agent could be recovered from tissues of these species for several days after they had received virus inoculations. |
| 2) Comparable NT titers for morphologically similar viruses (BLU and EHD) were not available because these agents plaque poorly on duck embryo cell monolayers. |
| |
| Immune Serum | Neut. Indices |
|---|
| | Ho | Ht *** |
|---|
|
| | * Ho obtained by plaque-reduction in Vero cells | | ** Ho obtained in fluid cultures of primary lamb kidney cells | | *** Ht obtained in NT test on duck embryo cell monlayers | | SLE (Parton) | 1.9 | <0.3 | | TUR(960) | 2.4 | <0.3 | | CTF(37) * | 5.9 | <0.3 | | BLU (8) ** | 4.0 | <0.3 | | BLU (262) ** | 4.2 | <0.3 | | BLU Ox183 ** | 4.5 | <0.3 | | EHD(NJ) | N.A. | <0.3 |
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| | NOTE: | Umatilla virus was determined to be antigenically related to Llano Seco virus by IFR and Cr (see Llano Seco virus registration card). |
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