| | | Using hyperimmune mouse ascitic fluids as well as hamster and guinea pig immune sera, Guanarito virus shows varying degrees of relationship to Junin, Machupo, Tacaribe, Amapari, Latino, Parana, Tamiami, Flexal, Pichinde, Sabia and LCM viruses by complement-fixation and immunofluorescent tests [1] . Guanarito antigen did not react with polyvalent group A, B, C, VSV, California grouping reagents. | | By cross-neutralization tests, Guanarito is distinct from Junin, Machupo, Lassa, Flexal, Amapari, Tacaribe, Sabia and LCM viruses [1] . | | | | Results of cross-neutralization tests with Guanarito and 7 other arenaviruses |
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| Source and Specificity of Antibody | LNI * of Antiserum against virus |
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| Species | Virus | GNT | JUN | MAC | LAS | LCM | FLE | AMA | TCR |
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| | * Log/10\ neutralization index. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | HMAF | Guanarito | 2.6 | 0.2 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.0 | | Human (IgG) | Junin | 0.0 | 2.2 | 0.1 | 0.1 | 0.0 | 0.1 | 0.0 | 0.0 | | GP (d31) | Junin | 0.2 | 2.7 | 0.2 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 | | Monkey | Machupo | 0.1 | 2.5 | >3.9 | 0.1 | 0.0 | 0.1 | 0.0 | 0.0 | | Human (IgG) | Lassa | 0.0 | 0.0 | 0.0 | 3.2 | 0.0 | 0.0 | 0.0 | 0.0 | | GP (d31) | LCM (Arm) | 0.1 | 0.2 | 0.2 | 0.3 | 1.3 | 0.1 | 0.0 | 0.0 | | GP (d273) | LCM (Arm/WE) | 0.0 | 0.1 | 0.1 | 0.1 | 3.7 | 0.1 | 0.0 | 0.0 | | MAF | Flexal | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.2 | 0.0 | 1.1 | | MAF | Amapari | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.0 | 1.5 | 0.0 | | HMAF | Tacaribe | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.3 |
| | GNT=Guanarito, JUN=Junin, MAC=Machupo, LAS=Lassa, LCM=lymphocytic choriomeningitis, FLE=Flexal, AMA=Amapari, TCR=Tacaribe. | | HMAF=hyperimmune mouse ascitic fluids (4 injections); GP(d31)=guinea pig (day 31 post-infection); GP)d2730=guinea pig (day 273 post-infection); MAF=mouse immune ascitic fluid (1 injection). | | |
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