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Arbovirus Catalog

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Virus Name/Prototype
Original Source
Method of Isolation
Virus Properties
Antigenic Relationship
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  Hantaan   HTNV

Possible Arbovirus

No

3

Results of SALS surveys and information from the Catalogue.
Other Information
DOC Permit Required, USDA Restricted 

3
Section IV - Virus Properties
Physicochemical
RNA, Single Strand
 

3 (29)


L=2.7x106M(S)




4

Nucleoprotein (N): 45-50,000 MW; glycoproteins (G1,G2): 55-56,000 MW, 72,000 MW; (L) 200,000 MW (30)



1.16-1.17; 1.20-1.21 in sucrose; CsCl2

450 S (31)(S)

1.19; 1.25 in sucrose; CsCl2

(S)

Stability of Infectivity (effects)

Maximum stability at pH 7.6; inactived at pH 3.0

20%

<1.0 dex

6.0 dex

5%

<1.0 dex

6.0 dex

0.1%

<1.0 dex

6.0 dex

Inactivated with 70% ethanol or 0.5% iodine; cobalt irradiation at 1.3x107 rads

Virion Morphology

Bunyavirus-like (24-28)

80-115 nm

nm

nm

Electron microscopy

Surface projections, 11-13 nm; lipid envelope


Morphogenesis



Cisternae of endoplasmic reticulum (28)

Seen with immunoperoxidase staining (28)


Hemagglutination

Yes

Apodemus lung tissue or A-549 cell cultures

Gander***

5.8-7.2

5.8-6.4

4dC, 25dC, 37dC

25dC

HA obtained with SMB extracted by sucrose-acetone and reacted with gooseRBC's(32) * Proposed genus designation** If the virus is handled in rodents, then Level 4. ***In addition to goose, Human O, rhesus monkey, guinea pig RBC's used

NT, IFA, immune adherence HA, HI

HA obtained with SMB extracted by sucrose-acetone and reacted with gooseRBC's(32) * Proposed genus designation** If the virus is handled in rodents, then Level 4. ***In addition to goose, Human O, rhesus monkey, guinea pig RBC's used
 
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