| | | Hantaan virus has been tested against the following NIAID reagent polyvalent antisera by indirect fluorescent antibody (IFA) tests utilizing strain 76-118 infected A-549 cells as substrate. All sera were negative (<1:10) unless otherwise indicated. Group C (Lot 2); GMA gr.; SIM gr.; VSV gr.; BUN gr.; CALgr.; TCR gr.; PHL gr.; polyvalent QRF, KSO, QYB, polyvalent grs. ANA, ANB, TUR; polyvalent BWA, MOS, NDO; polyvalent PAT; CAP gr.; polyvalent PAL, COR, EUB; KEM gr.; polyvalent CON, NSD; polyvalents 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 12; polyvalent rabies, LCM, NDV, herpes, vaccinia; coronavirus (OC-43) and coronavirus (229E). | | A weak atypical reaction was repeatedly observed at a 1:20 dilution of the Bunyamwera Group polyvalent MIAF. The following antisera prepared against individual BUN group viruses were tested by IFA with negative results (<1:10): | | |
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| | YARU Antisera | CDC-Ft. Collins Antisera | | BUN,BAT,ILE KRI,GRO,TAIASSUI | GER,LOK,WYO,TEN,MAG,SAR SOR,ANH,NOR,CV,BIR,SHO |
| | Of 161 monovalent HIAF raised against viruses of the Bunyaviridae, only the fluid to Anhembi virus reacted by IFA, at a titer of 16, to Hantaan virus [34] . | | In addition, a polyvalent monkey anti Lassa-Machupo-Junin serum prepared at USAMRIID titered <10 as did anti-RVF rabbit serum and anti-Congo and anti- Hazara mouse serum. Direct conjugates of polyvalent group A (Alphaviruses) and polyvalent group B (Flavi) were also negative. Similarly, human convalescent sera from Machupo, Lassa, Marburg, and Ebola infections provided by Dr. Karl Johnson were negative when tested by IFA against strain 76-118 infected Apodemus lung sections. | | The following virus complement-fixation (CF) antigens were tested by Dr. Robert Shope, YARU against two human KHF convalescent antisera. All CF tests were negative (<8). The human sera had Hantaan IFA titers of 320 and 640. AH, ACD, ACA, AKA, AMA, ANH, ANA, ANB, APEU, ARK, ARU, AMT, Abadina, BAN, BAK, BDA, BGN, BAU, BER, BHA, BLU, BOC, BTK, BUJ, BSB, BUT, BWA, BIA, AP, URU, BLM, CE, CDU, CAP, CHO, CHG, CHP, CGL, CHV, CNU, COC, CTF, CON, COR, COT, CR, Cedros, DEN-2, DGK, DHO, DUG, EEE, EHD, EUB, EgAn1398-61, Eret147, Farallon, FLA, GAM, GER, GA, GJA, GMA, GRO, GI, HAZ, HUA, HUG, ICO, IERI, ILE, IRI, ITP, ITQ, IbH11306, IbAn38918, Ichampadi, JOC, JAP, JOI, JUN, JUR, KK, KRI, KMP, KAN, KS, KAR, KEM, KC, KTR, KOO, KOW, KWA, KSO, KAM, KLA, kotonkan, LB, LJ, LJN, LEB, LD, LS, LUK, LCM, MAL, MAN, MAP, MCO, MTY, MAT, MEL, MNT, MIN, MIR, MOD, MOS, MEB, Mokola, NKO, NOLA, NYM, NDO, OKO, ORI, ORO, ORU, OLI, OYA, Obodhiang, PCA, PAC, PAL, PATA, PIC, PIRY, PT, QYB, QRF, Rabies, REO-3, SAL, SFN, SFS, SAT, SAW, SEM, SF, SIL, SIM, SOL, SLE, GF, TCM, TCR, TAM, TAT, TME, TEN, TETE, THI, THO, TPM, TNT, TUR, TSU, UMB, UPO, UUK, VEE, VSI, VSNJ, WM, WAL, WAN, WEE, WIT, WON, WYO, YATA, YF, YOG. | | Hantaan virus was shown to be antigenically related to, but distinct from the recently registered Prospect Hill virus, rat isolates of Hantaan-like viruses and the agent of nephropathia epidemica [33] . | | |
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