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Virus Name: Hantaan

Abbreviation: HTNV

Status
Possible Arbovirus

Select Agent
No

SALS Level
3

SALS Basis
Results of SALS surveys and information from the Catalogue.

Other Information
DOC Permit Required, USDA Restricted

Antigenic Group
3

Section VI - Biologic Characteristics

Virus Source (all VERTEBRATE isolates)
Blood (M), blood (LV), lung (LV), kidneys (LV), parotid gland(LV), saliva (LV), urine (LV), and feces (LV)

Lab Methods of Virus Recovery (ALL ISOLATIONS)
Apodemus agarius coreae (weanling or adult), Apodemus agrarius jejuensis (weanling or adult); alveolar type II cells derived from human lung carcinoma (A-549)(4).

Cell system (a)	Virus passage history (b)	Evidence of Infection
		CPE			PLAQUES			Growth Without CPE
		Day (c)	Extent (d)	Titer TCD50/ml (e)	Day (c)	Size (f)	Titer PFU/ml (e)	+/- (g)


^a Expressed in dex
^b Fluorescent foci forming units/ml. Ultimate titer and day of peak titer are directly proportional to input multiplicity within the range of 0.0001 - 10.
NOTE: CPE is not a characteristic feature of infection with HTN virus and early reports of CPE may be attributed to contaminating viruses.

A-549 (CL)	None	4-7	2+-4+	4-5 ^a				Sometimes
A-549 (CL)	Apodemus P1-P3	4-7	2+-4+	4-5				Sometimes
A-549 (CL)	Apodemus P5	10-14	0	2-4 ^b	Irregular	0-small	2-4 ^a	+
A-549 (CL)	A-549 P8	5-10	0	4-6 ^b	Irregular	0-small	4-6	+
WI-38 (CL)		5-10	0	4-6 ^b				+
MRC-5 (CL)		5-10	0	4-6 ^b				+
FRhL (CL)		5-10	0	4-6 ^b				+
FRhL (CL)	Apodemus P3	7-14	1+-3+	4-6 ^b				Sometimes
E6 (CL)	Various+ unpass.	>17	Irregular to none		6-8	1-4 mm	7.0	+ (24)

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