| | | | | Experimental host and age | Passage history and strain | Inoculation Route-Dose | Evidence of infection | AST (days) | Titer log10/ml | |
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| | Apodemus agrarius coreae, A. a. jejuensis and A. a. ningpoensis and 50% of Calomys callosus inoc im with various Apodemus (Ap) passage(P) levels of strain 76-118 develop FA detectable virus specific antigen in organs 18-21 days post inoc. Virus titers reach 7-8 log10/gram of lung tissue in Apodemus, and 2-4 log10 of virus in blood is demonstrable 7-10 days after inoculation (1,5). | | Saimiri sciureus inoc im with Ap P-3 of Lee strain (human isolate) develop FA antibody and most inoc animals develop clinical signs of varying severity. Low level viremia is demonstrable 17-24 days after inoc (2). | | Cercopithecus aethiops, Cebus apella, Callithrix jaccus, Maccaca mulatta, M. fasciculatus, S. sciureus, M. nemestrina, and Papio anubis inoc im with Ap P-5 76-118 or the 3rd A-549 TC passage of this virus, and Aotus trivirgatus inoc im with Ap P-3 Lee strain develop antibody with only occasional clinical signs or viremia (2,5). | | Rattus norvegicus, Sprague-Dawley and Wistar strain white rats, strain 13 and Hartley guinea pigs, New Zealand white rabbits, A. peninsulae**** and A. speciosus**** (Japan) inoc im with Ap P-5 or P-7 76-118 virus develop antibody without clinical signs or detectable antigen in their organs (2,5). However, HTN virus infects Wistar Fisher rats after adaptation. Antigen detected 14-64 days pi. Circulating antibodies detected in sera of infected rats (21). | | Gerbils (Meriones unguiculatus) newborns die after inoculation by ic or peripheral routes with Hantaan virus (36). | | Wistar female Rattus norvegicus 12-16 wks. old, infected by inhalation (44). | | **** Genus Apodemus | | | | ICR Mice (nb) | Apodemus P-7 | ic 0.025 | Death | 8-9 | 7.1 | | | Mice (nb) | A549 P4; E6 P18 | ip 0.03 | Death | | 4.8 | | | Mice (nb) | Strain76-118(41) | sc 0.025 | Death | | | | | Mice (wn) | | ic 0.03 | Irregular deaths | | | | | Mice (wn) | | ip | | | | | | Mice (ad) | | im 0.3 | No deaths, antibody prod. | | | | | Mice (nb) | | im,in 0.03 | Death | | 5.0 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
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