CDC Home
CDC 24/7: Saving Lives. Protecting People.™

Centers for Disease Control and Prevention

CDC 24/7: Saving Lives. Protecting People.™

Centers for Disease Control and Prevention CDC 24/7: Saving Lives. Protecting People.™
ARBOVIRUS A-Z Index
  1. A
  2. B
  3. C
  4. D
  5. E
  6. F
  7. G
  8. H
  9. I
  10. J
  11. K
  12. L
  13. M
  14. N
  15. O
  16. P
  17. Q
  18. R
  19. S
  20. T
  21. U
  22. V
  23. W
  24. X
  25. Y
  26. Z

Arbovirus Catalog

Browse the Catalog

ArboCat Home


Virus Sections

Virus Name/Prototype
Original Source
Method of Isolation
Virus Properties
Antigenic Relationship
Biologic Characteristics
Natural Host Range
Susceptibility to...
Experimental Infection...
Histopathology
Human Disease
Geographic Distribution
References
Remarks

References

History
Abbreviations
Information Exchange

User Functions

Login to Contribute
Create an Account
Retrieve Password
 

  Kaikalur   KAIV

Possible Arbovirus

No

2

Results of SALS surveys and information from the Catalogue.
Other Information
 

Simbu
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
Studies at the Virus Research Centre, Poona [1] :
No relationship was detected by the CF test with immune sera to the following viruses: Alphaviruses; CHIK, SIN. Flaviviruses; JE, WN, DEN, types 1, 2, 3, and 4, KFD, MVE, NTA, and LGT. Bunyaviruses; UMB, BAT, and KSO. Orbiviruses; AHS, type 2, and PAL. Rhabdovirus; CHP. Herpesvirus; herpes simplex. Reovirus; reovirus type 3. Orthomyxoviridae; DHO. Unclassified: VKT, Ichampadi, ARK, and MIN. In preliminary CF tests, relationship was established between VRC 713423-2 and Sathuperi virus.
The results of neutralization tests in infant mice with 713423-2, Sathuperi and Ingwavuma viruses and the respective homologous and heterologous immune sera were as follows:
 
Virus
Immune sera 713423-2 Sathuperi Ingwavuma
Titre LNI a Titre LNI Titre LNI


a LNI in dex.
713423-2 <2.0 > 4.5 > 6.7 +1.0 6.5 0.2
Sathuperi 4.2 2.3 2.7 > 5.0 ND
Normal mouse serum 6.5 > 7.7 6.7
BAPS control titrations 6.0 > 7.6 6.6
Studies at Yale University School of Medicine:
Neutralization tests in Vero cells were conducted with 713423-2 virus and mouse immune ascitic fluid (MIAF) to the following viruses belonging to the Simbu group: AKA, BUT, ING, MAN, MER, ORO, SABO, SAN, SHA, SHU, SIM, THI, Utinga, and Yaba 7. 713423-2 was neutralized only by MIAF to Shuni virus. The relationship between 713423-2 and Shuni and Sathuperi viruses is shown by the following results of neutralization tests in Vero cells:
 
Virus
713423-2 Shuni Sathuperi
MIAF Virus dose (dex) Titre bLNI c Virus dose (dex) Titre LNI Virus dose (dex) Titre LNI


b Serum dilution neutralization endpoints vs. 100 TCD50.
c Constant serum-varying virus dilution neutralization indices in dex.
713423-2 1.8 320 >4.35 1.5 240 >4.0 2.3 60 2.5
Shuni 1.5 210 3.0 2.0 >1280 >4.0 1.7 90 3.7
Sathuperi 1.8 80 2.85 2.0 70 3.0 2.0 >1280 >4.3
713423-2 is closely related to Shuni virus but the sixfold or higher difference in titres of Shuni MIAF when tested with Shuni and 713423-2 viruses, respectively, indicate that they are not identical.
 
Download as PDF
<<<Click on the PDF icon to the left to view a copy of this virus entry in PDF format.
You can get a copy of the PDF viewer by clicking here.
 

Policies

Privacy

Contact Information

Centers for Disease Control and Prevention
1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636)
Contact CDC-INFO