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Virus Name:
Lednice
Abbreviation:
LEDV
Status
Probable Arbovirus
Select Agent
No
SALS Level
2
SALS Basis
Placed at this biosafety level based on close antigenic or genetic relationship to other viruses in a group of 3 or more viruses, all of which are classified at this level.
Other Information
Antigenic Group
Turlock Group
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
Identification test [1] using serum Lednice in dilutions 1:4 to 1:64 and 68 different arbovirus antigens in CF test were negative. Lednice antigen diluted 1:4 and 1:16 examined in CF test against 47 monotypic immune ascitic fluids or sera and 18 group polyvalent ascitic fluids or sera reacted positively only with polyvalent immune ascitic fluid containing antibodies against the arboviruses Anopheles A - Anopheles B - Turlock groups. Subsequently from all available antigens in the positive set, only the antigens of the Turlock group reacted with the Lednice serum. The results of final CF tests showed that Lednice and Yaba-1 viruses are close. The CF results were confirmed in the NT in mice.
Antibody
Antigen
Lednice
Yaba-1
DakBA 365
Serum titer/antigen titer; 0 = <4/<4
Lednice
128/256
*
16/128
8/128
Yaba 1
64/512
16/256
8/256
DakBA 365
64/32
16/16
8-16/32
Control antigen
0
0
0
The table below give NT results obtained by cross-testing Turlock serogroup viruses in Vero cells [22] . Neutralization titers represent serum dilution endpoints causing 90% plaque reduction.
Antibody to:
Virus
6118
MPO
Yaba-1
TUR
UMB
6118
1280
320
320
2560
40
M'Poko
160
10240
5120
5120
20
Yaba-1
160
2560
1280
1280
40
Turlock
40
80
40
2560
80
Umbre
80
640
40
1280
1280
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