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  Machupo   MACV

Not Arbovirus

Yes

4

Results of SALS surveys and information from the Catalogue.
Other Information
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Tacaribe
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
 
CF Test
Antibody
Antigen Machupo Junin Tacaribe


Machupo 128 64 128
Junin 64 256 256
Tacaribe 64 128 512
 


Antigens: Sucrose-acetone extracted infected hamster (Machupo), or mouse (Junin, Tacaribe) brains. 2-4 units in test, as determined by homologous box titrations. Hamster antiserum (Machupo) obtained after 4 weekly IP injections 0.1 ml SHB virus; Ascitic fluid produced in mice (Junin, Tacaribe) by repeated IP injections SHB virus with equal parts Freunds' complete adjuvant.
 
Neutralization Test
Antibody
Virus Machupo Junin Tacaribe


Machupo 3.0 0 0
Junin 0 4.0 1.0
Tacaribe 0 0 3.5
Dex virus neutralized, rounded off to nearest 0.5 dex. Test in continuous rabbit kidney cells (MA-111) and viruses estimated by plaques production [3] .
Antisera to influenza A and B, parainfluenza types 1-4, mumps, Newcastle and LCM viruses failed to react in CF test with Machupo antigen. LCM CF antigen did not fix complement in presence of Machupo antiserum. Junin virus has been exhaustively tested by CF test against other known and suspected arboviruses with negative results [2] .
Human sera collected following infection with Machupo virus give positive CF with Junin antigen [3] . Serologically related to LCM and other members of Tacaribe serogroup [9] .
 
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