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  Middelburg   MIDV

Arbovirus

No

3

Disease is sheep, cattle, or horses.
Other Information
 

A
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
 
MID Antigen [15] MID Antibody [15]
Immune fluids HI CF Antigens HI CF


Results expressed as quotient of homologous/heterologous titers.
Chikungunya >1280 >128 Chikungunya >2560 >512
Sindbis 640 >512 Sindbis >2560 32
Semliki Forest >1280 256 Semliki Forest >2560 8
Ndumu 640 32 Ndumu Not done 32
In cross-PRNT [4] there was slight (1/10) neutralization of MID virus by Ross River and Ndumu antisera but no reactions either way with western equine enc., Sindbis, Whataroa, Aura, Ven. equine enc., Mucambo, Pixuna, Semliki Forest, Mayaro, chikungunya, Una, o'nyong-nyong, Bebaru, Getah, and east. equine enc.
Showed no relationship to 21 alphaviruses by neutralization test in micro- cell cultures [5] .
Placed in WEE serological subgroup as a distantly related member [2] . SIRACA has determined that MID virus is not antigenically closely related to any other group A virus. It has been placed in a separate complex within serogroup A [24] .
 
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