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Virus Name: Modoc

Abbreviation: MODV

Status
Not Arbovirus

Select Agent
No

SALS Level
2

SALS Basis
Results of SALS surveys and information from the Catalogue.

Other Information

Antigenic Group
B

Section V - Antigenic Relationship and Lack of Relationship to Other Viruses

	Modoc Antigen				Modoc Immune Serum
Immune Serum	HI	CF	NT	Antigen	HI	CF	NT


HI, CF, NT: Ho/Ht; NT=LNI in dex.
Powassan	0/160			Powassan	40/5120
RSSE	160/5120			RSSE	320/5120	8/256
SLE	640/10,240			SLE	1280/5120	64/256
Ilheus	320/5120			Ilheus		64/256
Rio Bravo	320/5120	0/16	<0.5/>2.0	Rio Bravo	1280/5120	61/256	<0.5/>6.0
Bussuquara	0/320

Cross immunity tests: Not related to Powassan. One way cross with Rio Bravo, i.e., Modoc immunized mice resist IC challenge one month later with Rio Bravo virus; Rio Bravo immunized mice do not resist challenge one month later with Modoc virus. No cross immunity with SLE [5] .

By CF and NT, Modoc virus was most closely related to but antigenically distinct from Cowbone Ridge, Jutiapa, San Perlita and Sal Vieja viruses [11] .

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