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  Okola   OKOV

Possible Arbovirus

No

2

Results of SALS surveys and information from the Catalogue.
Other Information
 

Ungrouped
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
HI test against mouse sera of following viruses gives negative results:
chikungunya, o'nyong nyong, Middleburg, Ndumu, Semliki Forest virus, Sindbis, Ntaya, Wesselsbron, Usutu, yellow fever, Uganda S, Dakar bat, West Nile, Zika, Spondweni, Entebbe bat, dengue 1.
Bunyamwera, Ilesha, Shokwe.
Bwamba, Pongola.
Simbu, Ingwavuma.
Lumbo, Chenuda, Mossuril, Nyamanini, Lagos bat, Nyando, Olifantsvlei, African horse sickness, Tataguine, Nairobi sheep disease, Thogoto, Witwatersrand.
In NT tests, negative reactions were found to the following sera against 63 LD50 of YM 50/64.
 


Group A: Group Bunyamwera:
Chikungunya (>2.2) Bunyamwera
O'nyong nyong (2.3) Ilesha (>2)
Middelburg (1.9) Germiston (>3.9)
Ndumu
Semliki (>2.5) Group Bwamba:
Sindbis (>5.5) Bwamba (>2.5)
Group B: Pongola (>2.5)
Ntaya ( 2.7)
Wesselsbron (>2.3) Group Simbu:
Usutu Simbu (>2)
Yellow fever (>3.2)
Uganda S (>2.8) Non groups:
Dakar bat ( 2.3) Chenuda (>2.1)
West Nile ( 3.2) Lumbo (>3)
Zika (>2.4) Mossuril (>1.5)
Spondweni (>3.9) Nyamanini ( 2)
Entebbe bat Nyando ( 2.5)
Lagos bat
( ): Homologous neutralization by reference sera; shown as LNI expressed in dex; blank = not determined
CF test (EAVRI, Entebbe): Homologous titre = 160/80
In screening tests, YM 50 antigen gave negative results with following hyperimmune fluids from mice:
Bunyamwera, Germiston, Ilesha, Shokwe
Bwamba, Pongola. Simbu, Ingwavuma.
Quaranfil, Chenuda, Nyando, Eretmapodites 147, African horse sickness, Tataguine, Lagos bat, Lebombo, Lumbo, Matruh, Mossuril, Nairobi sheep disease, Nyamaninni, Olifantsvlei, Tanga, Thogoto, Witwatersrand, Congo, AMP 5438, AR 1169, AR 1225, AR 1275, Arumowot, Acado.
Okola virus is related to Tanga virus by IFA. Only Okola virus reacted by IFA with antibodies to Anhembi, Birao, Cache Valley, Northway, Tensaw, Tlacotalpan and Santa Rosa viruses. Antibody to Tanga and Okola viruses did not react by IFA with antigens of these viruses [6] .
 
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