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Virus Name: Pichinde

Abbreviation: PICV

Status
Not Arbovirus

Select Agent
No

SALS Level
2

SALS Basis
Level 2 arenaviruses are not known to cause serious acute disease in man and are not acutely pathogenic for laboratory animals, including primates. Survey experience is sufficient to conclude that laboratory aerosol infection does not occur in the course of routine work with cell cultures and animals not subject to chronic infection. In view of reported high frequency of laboratory aerosol infection that occurred in workers manipulating high concentrations of Pichinde virus, it is strongly recommended that work with high concentrations of Level 2 arenaviruses be done at Level 3.

Other Information

Antigenic Group
Tacaribe

Section V - Antigenic Relationship and Lack of Relationship to Other Viruses

Pichinde crude brain antigen did not react in CF with mouse immune ascitic fluids for A, B, C, and Bunyamwera groups, Tacaribe, Junin, Machupo and Amapari. A low titer (4/10) CF result was observed with Tacaribe group MIAF. By plaque NT the virus also was shown to be different from Tacaribe, Juninn, Machupo, Amapari and Tamiami [1] . Further CF tests with all known members of the Tacaribe group indicated that Pichinde is related to Tamiami [2] , [3] .

Results of Complement-fixation tests [2]
	Immune ascitic fluid
	Pichinde	Tamiami
Antigen	An 3739	W-10777


^* Serum titer/antigen titer
Pichinde	>256/32 ^*	4/4
Tamiami	64/>64	128/> 128

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