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Virus Name: Semliki Forest

Abbreviation: SFV

Status
Arbovirus

Select Agent
No

SALS Level
3

SALS Basis
Fatal human laboratoryinfection, 1978, probably aerosol. This is recognized to be a unique incident in a long history of work with SFV under minimal biocontainment conditions. However, since the virulence characteristics of the strain responsible in this case require further study and the prevalence of subclinical infections in laboratories working with SFV remains unknown, the committee recommends Level 3 until further information is available warranting reconsideration at a lower level.

Other Information

Antigenic Group
A

Section VI - Biologic Characteristics

Virus Source (all VERTEBRATE isolates)

Lab Methods of Virus Recovery (ALL ISOLATIONS)
Newborn and weanling mice

Cell system (a)	Virus passage history (b)	Evidence of Infection
		CPE			PLAQUES			Growth Without CPE
		Day (c)	Extent (d)	Titer TCD50/ml (e)	Day (c)	Size (f)	Titer PFU/ml (e)	+/- (g)


CPE and plaques in chick embryo (PC) (13), duck embryo (PC) and rhesus monkey kidney (PC) (43), BHK-21 (CL) and Vero (CL) (35). CPE in the HeLa (CL) (44) and mouse embryo cells (PC) (24). Multiplication in Aedes aegypti and Ae albopictus cell lines (36).
** Expressed in dex

Vero (CL)	SM 14				2	20 mm	9.3** (45)
LLC-MK2 (CL)					3	9 mm	10.0 (45)

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