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  Tehran   TEHV

Possible Arbovirus

No

2

Placed at this biosafety level based on close antigenic or genetic relationship to other viruses in a group of 3 or more viruses, all of which are classified at this level.
Other Information
 

Phlebotomus Fever
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
Results of HI test [2] .
 
Antisera to:
Antigens Karimabad Tehran Naples Sicilian Salehabad


a HI titers with 8 HA units of antigen; 0 = <1:20
Karimabad 640 a 0 40 0 80
Tehran 640 320 640 0 80
Naples 640 160 1280 0 20
Sicilian 40 0 0 1280 0
Salehabad 320 0 20 0 320
Results of CF and plaque-reduction neutralization tests (PRNT) [4] .
 
CF PRNT
Antibody to: Antibody to:
Antigen/Virus Naples ISS.Phl.3 Tehran Naples ISS.Phl.3 Tehran


b Highest serum titer/highest antigen titer
c Reciprocal of highest serum dilution giving >90% plaque reduction.
Naples 256/128 b 64/64 128/128 320 c 10 <10
ISS.Phl.3 128/256 256/> 512 128/256 20 > 5120 <10
Tehran 128/64 64/64 256/128 <10 <10 80
In cross-neut. tests, Tehran virus and immune serum did not react with: AGU, ALE, ANH, AMT, BUE, BUJ, CAC, CAI, CDU, CHG, CHI, FRI, GF, GOR, ICO, ITA, ITP, KAR, NIQ, PAC, PT, RVF, RG, SAF, SAL, SFS, TRA, or URU viruses or immune sera [4] .
 
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