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Virus Name:
Cacipacore
Abbreviation:
CPCV
Status
Possible Arbovirus
Select Agent
No
SALS Level
3
SALS Basis
Isufficient experience with virus; i.e., experience factor from SALS surveys was less than 500 in laboratory facilities with low biocontainment.
Other Information
Antigenic Group
B
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
Serological studies conducted in Brazil demonstrated that Cacipacore virus was a group B arbovirus, and that it was different from other known flaviviruses of the Amazon (see tables below). At YARU, additional CF tests indicated it was in the JE-MVE-WN complex, but different from any of the known members tested [1] . Subsequent addtitional cross-neutralization tests with 63 other flaviviruses showed that Cacipacore virus was distinct from all other flaviviruses. It did not share a close antigenic relationship with any of the flaviviruses, and thus could not be placed in any of the complexes comprising serogroup B [2] .
Complement-Fixation Test
Antigens
BeAn 327600
YF
BSQ
ILH
SLE
ROC
Group B
a
Serum titer/antigen titer: 0 - <4/<4
BeAn 327600
16/>64
a
0
0
4/4
4/16
16/4
16/4
Yellow fever
0
64/>64
16/>64
Bussuquara
0
64/>64
32/>64
Ilheus
0
64/>64
64/>64
SLE
4/64
64/>64
>128/64
Rocio
0
>128/64
16/>64
Neutralization Test (Newborn Mice, ic Route)
Viruses
BeAn 327600
YF
BSQ
ILH
SLE
ROC
Group B
b
LNI in dex
BeAN 327600
4.7
b
1.0
0.9
2.1
1.9
2.3
2.8
Yellow fever
4.2
Bussuquara
0.5
3.5
3.4
Ilheus
<=1.0
5.0
3.7
SLE
0.7
3.0
3.0
Rocio
<=1.9
5.0
<=3.9
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