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  Cacipacore   CPCV

Possible Arbovirus

No

3

Isufficient experience with virus; i.e., experience factor from SALS surveys was less than 500 in laboratory facilities with low biocontainment.
Other Information
 

B
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
Serological studies conducted in Brazil demonstrated that Cacipacore virus was a group B arbovirus, and that it was different from other known flaviviruses of the Amazon (see tables below). At YARU, additional CF tests indicated it was in the JE-MVE-WN complex, but different from any of the known members tested [1] . Subsequent addtitional cross-neutralization tests with 63 other flaviviruses showed that Cacipacore virus was distinct from all other flaviviruses. It did not share a close antigenic relationship with any of the flaviviruses, and thus could not be placed in any of the complexes comprising serogroup B [2] .
 
Complement-Fixation Test
Antigens BeAn 327600 YF BSQ ILH SLE ROC Group B


a Serum titer/antigen titer: 0 - <4/<4
BeAn 327600 16/>64 a 0 0 4/4 4/16 16/4 16/4
Yellow fever 0 64/>64 16/>64
Bussuquara 0 64/>64 32/>64
Ilheus 0 64/>64 64/>64
SLE 4/64 64/>64 >128/64
Rocio 0 >128/64 16/>64
 
Neutralization Test (Newborn Mice, ic Route)
Viruses BeAn 327600 YF BSQ ILH SLE ROC Group B


b LNI in dex
BeAN 327600 4.7 b 1.0 0.9 2.1 1.9 2.3 2.8
Yellow fever 4.2
Bussuquara 0.5 3.5 3.4
Ilheus <=1.0 5.0 3.7
SLE 0.7 3.0 3.0
Rocio <=1.9 5.0 <=3.9
 
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