Prevention Research Synthesis
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Pre-Exposure Prophylaxis Evidence-Based Intervention

Intended population: HIV-negative men who have sex with men (MSM) and transgender persons

Intervention effects/outcomes: Improved PrEP adherence

Study years: 2015 – 2018

Structural components: None reported


van den Elshout, M. A. M., Hoornenborg, E., Achterbergh, R. C. A., Coyer, L., Anderson, P. L., Davidovich, U., de Vries, H. J. C., Prins, M., Schim van der Loeff, M. F., & Amsterdam PrEP Project Team in the HIV Transmission Elimination Amsterdam Initiative (H-TEAM). (2021). Improving adherence to daily preexposure prophylaxis among MSM in Amsterdam by providing feedback via a mobile application. AIDS, 35(11), 1823-1834. doi: 10.1097/QAD.0000000000002949

Risk Reduction Evidence-Based Intervention (Good)

Intended population: Young Black or African American men who have sex with men (YBMSM) and transgender women (TW)

Intervention effects/outcomes: Increased HIV self-testing

Study years: 2016 – 2017

Structural components: Access, Physical Structure


Frye, V., Nandi, V., Paige, M. Q., McCrossin, J., Lucy, D., Gwadz, M., Sullivan, P., Hoover, D., Wilton, L., & TRUST Study Team. (2021). TRUST: Assessing the efficacy of an intervention to increase HIV self-testing among young Black men who have sex with men (MSM) and transwomen. AIDS and Behavior, 25(4), 1219-1235. doi: 10.1007/s10461-020-03091-x 

Risk Reduction Evidence-Based Intervention (Best)

Intended population: Immigrant Hispanic/Latino gay, bisexual, and other men who have sex with men (GBMSM) who speak Spanish; Immigrant Hispanic/Latina transgender women (TW) who speak Spanish

Intervention effects/outcomes: Increased HIV testing

Study years: 2011 – 2018

Structural components: Condom use models, HIV/STI informational brochures, Risk reduction supplies, Videos


Rhodes, S. D., Alonzo, J., Mann-Jackson, L., Song, E. Y., Tanner, A. E., Garcia, M., Smart, B. D., Baker, L. S., Eng, E., & Reboussin, B. A. (2020). A peer navigation intervention to prevent HIV among mixed immigrant status Latinx GBMSM and transgender women in the United States: outcomes, perspectives and implications for PrEP uptake. Health Education Research, 35(3), 165-178. doi: 10.1093/her/cyaa010