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PRS Compendium Featured Interventions

This month's feature focuses on the newest interventions added to the Compendium. M-Cubed is an individual-level digital health intervention that uses a status neutral approach via a mobile app to address multiple HIV prevention and care needs for GBMSM with and without HIV. Positive Health Check is a patient-centered, brief video intervention designed to improve viral load suppression and retention in HIV care for PWH who are newly diagnosed, new to care, or engaged in care but not virally suppressed. PrEPare-to-Start is a brief behavioral intervention for PrEP uptake that uses motivational interviewing to help participants decide whether to start taking PrEP. iENGAGE is individually tailored to improve information, motivation, and behavioral skills to promote treatment adherence and viral suppression.

M-Cubed (Mobile Messaging for Men)

PubMed record

Risk Reduction Evidence-Based Intervention (Best)

Intended population: Gay, bisexual, and other men who have sex with men (GBMSM)

Intervention effects/outcomes: Increased HIV testing, Increased PrEP

Study years: 2018 – 2019

Structural components: None reported

Sullivan, P. S., Stephenson, R., Hirshfield, S., Mehta, C. C., Zahn, R., Bauermeister, J. A., Horvath, K., Chiasson, M. A., Gelaude, D., Mullin, S., Downing, M. J., Olansky, E. J., Wiatrek, S., Rogers, E. Q., Rosenberg, E., Siegler, A. J., & Mansergh, G. (2022). Behavioral efficacy of a sexual health mobile app for men who have sex with men: Randomized controlled trial of Mobile Messaging for Men. Journal of Medical Internet Research, 24(2), e34574. doi: 10.2196/34574

Positive Health Check

PubMed record

Linking and Retention Evidence-Based Intervention

Intended population: People with a new HIV diagnosis; People with HIV (PWH) engaged in care who are not virally suppressed; People with HIV (PWH) who are new to care

Intervention effects/outcomes: Improved retention in HIV care; Improved viral suppression

Study years: 2018 – 2020

Structural components: None reported

Lewis, M. A., Harshbarger, C., Bann, C., Marconi, V. C., Somboonwit, C., Dalla Piazza, M., Swaminathan, S., Burrus, O., Galindo, C., Borkowf, C. B., Marks, G., Karns, S., Zulkiewicz, B., Ortiz, A., Iddrisu, A., Garner, B. R., Courtenay-Quirk, C., & Positive Health Check Study Team. (2022). Effectiveness of an interactive, highly tailored ‘Video Doctor’ intervention to suppress viral load and retain patients with HIV in clinical care: A randomized clinical trial. JAIDS Journal of Acquired Immune Deficiency Syndromes, 91(1), 58-67. doi: 10.1097/QAI.0000000000003045

PrEPare-to-Start

PubMed record

Pre-Exposure Prophylaxis Evidence-Based Intervention

Intended population: Men who have sex with men (MSM) with behavioral risk factors for HIV

Intervention effects/outcomes: Improved linkage to PrEP care

Study years: 2019 – 2020

Structural components: None reported

Chan, P. A., Nunn, A., van den Berg, J. J., Cormier, K., Sowemimo-Coker, G., Napoleon, S. C., Arnold, T., & Moitra, E. (2021). A randomized trial of a brief behavioral intervention for PrEP uptake among men who have sex with men at increased risk for HIV infection. JAIDS Journal of Acquired Immune Deficiency Syndromes, 87(3), 937-943. doi: 10.1097/QAI.0000000000002671

iENGAGE (Integrating ENGagement and Adherence Goals upon Entry)

PubMed record

Structural Evidence-Based Intervention

Intended population: People with HIV (PWH) who are new to care

Intervention effects/outcomes: Reduced internalized HIV stigma

Study years: Not reported

Structural components: Capacity Building, Social Determinants of Health

Yigit, I., Modi, R. A., Weiser, S. D., Johnson, M. O., Mugavero, M. J., Turan, J. M., & Turan, B. (2020). Effects of an intervention on internalized HIV-related stigma for individuals newly entering HIV care. AIDS, 34(Suppl 1), S73-S82. doi: 10.1097/QAD.0000000000002566