Prevention Research Synthesis
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PRS Compendium Featured Interventions

Here are a number of the newest interventions identified by the PRS Project.
ChiCAS (Chicas Creando Acceso a la Salud or Girls Creating Access to Health)
PubMed record
Pre-Exposure Prophylaxis Evidence-Based Intervention

Intended population: Transgender women who speak Spanish and are HIV-negative

Intervention effects/outcomes: Increased PrEP use

Study years: 2019 – 2022

Structural components: None reported


Rhodes, S. D., Alonzo, J., Mann-Jackson, L., Aviles, L. R., Tanner, A. E., Galindo, C. A., Bessler, P. A., Courtenay-Quirk, C., Garcia, M., Sucaldito, A. D., Smart, B. D., Goldenberg, T., & Reboussin, B. A. (2024). PrEP uptake among Spanish-speaking transgender women: A randomized controlled trial in North and South Carolina, 2019-2022. American Journal of Public Health, 114(1), 68-78. doi: 10.2105/AJPH.2023.307444

HIV PrEP Services for Urban Women
PubMed record
Pre-Exposure Prophylaxis Evidence-Informed Intervention

Intended population: Healthcare providers in an urban sexual health clinic

Intervention effects/outcomes: Increased PrEP prescription/initiation for female clinic patients, Increased PrEP persistence for female clinic patients

Study years: 2018 – 2019

Structural components: Access, Capacity Building, Policy/Procedure


Scott, R. K., Deyarmond, M., Marwitz, S., Huang, J. C., Moriarty, P., Visconti, A. J., Beverley, J., Elion, R., Coleman, M., & Hull, S. J. (2023). Implementation of an educational intervention to improve HIV pre-exposure prophylaxis services for women in an urban sexual health clinic. AIDS Patient Care and STDs, 37(9), 447-457. doi: 10.1089/apc.2023.0107

Suppression Bundle
PubMed record
Structural Evidence-Informed Intervention

Intended population: Patients at HIV clinics with non-suppressed viral loads

Intervention effects/outcomes: Increased viral suppression

Study years: 2018

Structural components: Access, Social Determinants of Health


Poplin, V., Katz, J., Herrman, M., Robertson, K., Chen, G., Clough, L. A. & Newman, J. R. (2023). Effectiveness of a “Suppression Bundle” to improve HIV virologic suppression in an outpatient infectious disease clinic: A pilot implementation study. AIDS Care, 35(7), 1064-1068. doi: 10.1080/09540121.2022.2040720

Multicomponent Support Strategies
PubMed record
Linking and Retention Evidence-Informed Intervention

Intended population: People with HIV (PWH) in clinical care, PWH experiencing homelessness

Intervention effects/outcomes: Increased viral suppression

Study years: 2018 – 2021

Structural components: Physical Structure, Policy/Procedure, Social Determinants of Health


Spinelli, M. A., Le Tourneau, N., Glidden, D. V., Hsu, L., Hickey, M. D., Imbert, E., Arreguin, M., Jain, J. P., Oskarsson, J. J., Buchbinder, S. P., Johnson, M. O., Havlir, D., Christopoulos, K. A., & Gandhi, M. (2022). Impact of multicomponent support strategies on human immunodeficiency virus virologic suppression rates during coronavirus disease 2019: An interrupted time series analysis. Clinical Infectious Diseases, 75(1), e947–e954. doi.org/10.1093/cid/ciac179