Prevention Research Synthesis
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Target population: HIV-negative (or unknown status) men who have sex with men (MSM) in the United States

Intervention effects/outcomes: Increased HIV testing; Increased newly identified HIV infections

Study years: 2015 – 2016

Structural components: Access, Physical Structure (services in a non-traditional setting)


MacGowan, R. J., Chavez, P. R., Borkowf, C. B., Owen, S. M., Purcell, D. W., Mermin, J. H., Sullivan, P. S., & eSTAMP Study Group. (2020). Effect of internet-distributed HIV self-tests on HIV diagnosis and behavioral outcomes in men who have sex with men: A randomized clinical trial. JAMA Internal Medicine, 180(1), 117–125.

Structural Evidence-Based Intervention

Target population: Residents of urban and peri-urban communities in Zambia and Western Cape Province, South Africa

Intervention effects/outcomes: Reduced HIV incidence at a population level

Study years: 2013 – 2018

Structural components: Access, Physical Structure (services in a non-traditional setting)


Hayes, R. J., Donnell, D., Floyd, S., Mandla, N., Bwalya, J., Sabapathy, K., Yang, B., Phiri, M., Schaap, A., Eshleman, S. H., Piwowar-Manning, E., Kosloff, B., James, A., Skalland, T., Wilson, E., Emel, L., Macleod, D., Dunbar, R., Simwinga, M., . . . HPTN 071 (PopART) Study Team. (2019). Effect of universal testing and treatment on HIV incidence - HPTN 071 (PopART). New England Journal of Medicine, 381(3), 207-018.

Structural Evidence-Based Intervention

Target population: Adults who tested positive for HIV and who are antiretroviral treatment (ART)-naïve

Intervention effects/outcomes: Improved engagement in HIV care; Improved viral suppression

Study years: 2016 – 2017

Structural components: Access, Physical Structure (services in a non-traditional setting), Policy/Procedure


Labhardt, N. D., Ringera, I., Lejone, T. I., Klimkait, T., Muhairwe, J., Amstutz, A., & Glass, T. R. (2018). Effect of offering same-day ART vs usual health facility referral during home-based HIV testing on linkage to care and viral suppression among adults with HIV in Lesotho: The CASCADE randomized clinical trial. JAMA Journal of the American Medical Association, 319, 1103-1112.

Structural Evidence-Informed Intervention

Target population: Veterans with HIV

Intervention effects/outcomes: Increased ART adherence; Increased CD4 count; Increased HIV viral suppression

Study years: 2014 – 2015

Structural components: Access, Capacity Building, Physical Structure


Bagwell, A., McFarland, M. S., & Hulgan, T. (2018). An innovative approach to addressing the HIV care continuum: Implementation of a clinical pharmacy resident in a veteran’s affairs HIV specialty clinic. Journal of Pharmacy Practice, 31(5), 422-428.

Target population: HIV-negative men who have sex with men (MSM)

Intervention effects/outcomes: Increased HIV testing; Decreased multiple male sex partnerships

Study years: 2015 – 2016

Structural components: Access, Physical Structure (services in a non-traditional setting)


Wang, Z., Lau, J. T. F., Ip, M., Ho, S. P. Y., Mo, P. K. H., Latkin, C., Ma, Y. L., & Kim, Y. (2018). A randomized controlled trial evaluating efficacy of promoting a home-based HIV self-testing with online counseling on increasing HIV testing among men who have sex with men. AIDS and Behavior, 22(1), 190-201.