National Health and Nutrition Examination Survey

2010-2010 Data Documentation, Codebook, and Frequencies

Hemagglutination inhibition antibody titers to influenza A/ H1N1 viruses (Surplus) (SSHN10_R)

RDC Only Data File: SSHN10_R.xpt

First Published: July 2013

Last Revised: NA

Due to disclosure issues, this dataset is not available publicly. Access may be obtained through the NCHS Research Data Center (https://www.cdc.gov/rdc).

Component Description

Among a sample of participants of all ages collected during the year 2010, the antibody testing of stored sera specimens from NHANES 2009–2010 was conducted to determine population levels of pre-pandemic cross reactive antibody to the 2009 pandemic influenza A/H1N1 virus and related influenza viruses prior to the spread of the novel 2009 H1N1 virus. This data release contains the hemagglutination inhibition assay titers to 2009 H1N1 and three contemporary influenza viruses.

Eligible Sample

A sample of participants across all ages during the year 2010 from NHANES 2009-10 with stored sera.

Description of Laboratory Methodology

Antibody titers against 2009 H1N1 and three contemporary influenza viruses were measured with the hemagglutination inhibition (HI) assay following standard procedures by Focus Diagnositcs, Inc., Cypress, CA.

The selected virus targets were A/California/7/2009, A/Brisbane/59/2007, A/Perth/16/2009, B/Brisbane/60/2008.

The HI assay for each target virus was performed in triplicate. The geometric mean HI titers are reported. An HI titer of ≥40 indicates prior infection with an influenza virus antigenically similar to the tested virus

Data Processing and Editing

Data was received after all the antibody testing was complete. The data were not edited.

Data Access: Data is available from the Research Data Center (RDC).

Laboratory Quality Assurance and Monitoring

Commercial reagents were used for all testing. All QC procedures recommended by the manufacturers were followed.

Analytic Notes

There are four variables:

SSH1N1CA: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H1N1 virus A/California/7/2009
Continuous variable - Values range from <10 (the limit of detection) to 10240

SSH1N1BR: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H1N1 virus A/Brisbane/59/2007Continuous variable - Values range from <10 (the limit of detection) to 10240

SSH3N2PR: Geometric mean hemagglutination inhibition (HI) titer against the influenza AH3N2 virus A/Perth16/2009
Continuous variable - Values range from <10 (the limit of detection) to 10240

SSH3N2BR: Geometric mean hemagglutination inhibition (HI) titer against the influenza A/H3N2 virus B/Brisbane/60/2008
Continuous variable - Values range from <10 (the limit of detection) to 640

Values Listed < 10 the LOD will be released as 5.

References

Garten RJ, Davis CT, Russell CA, et al. Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science 2009; 325(5937):197-201.
Hancock K, Veguilla V, Lu X, et al. Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med 2009; 361(20):1945-52.
Veguilla V, Hancock K, Schiffer J, et al. Sensitivity and Specificity of Serologic Assays for Detection of Human Infection with 2009 Pandemic H1N1 Virus in U.S. Populations. J Clin Microbiol 2011; 49(6):2210-5.

Codebook and Frequencies

SEQN - Respondent sequence number

Variable Name:: SEQN
SAS Label:: Respondent sequence number
English Text:: Respondent sequence number.
Target:: Both males and females 0 YEARS - 150 YEARS

SSH1N1CA - Influenza A/HIN1A/California/7/2009

Variable Name:: SSH1N1CA
SAS Label:: Influenza A/HIN1A/California/7/2009
English Text:: Titer against Influenza A/HIN1A/California/7/2009 l/L)
Target:: Both males and females 0 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 10240	Range of Values	3330	3330
.	Missing	0	3330

SSH1N1BR - Influenza A/H1N1 virus/Brisbane/59/2007

Variable Name:: SSH1N1BR
SAS Label:: Influenza A/H1N1 virus/Brisbane/59/2007
English Text:: Titer against influenza A/H1N1 virus/Brisbane/59/2007
Target:: Both males and females 0 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 10240	Range of Values	3330	3330
.	Missing	0	3330

SSH3N2PR - Influenza A9H3N2 virus A/Perth 16/2009

Variable Name:: SSH3N2PR
SAS Label:: Influenza A9H3N2 virus A/Perth 16/2009
English Text:: Titer against influenza A9H3N2 virus A/Perth 16/2009
Target:: Both males and females 0 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 10240	Range of Values	3330	3330
.	Missing	0	3330

SSH3N2BR - Influenza A/H3N2 virus B/Brisban/60/2008

Variable Name:: SSH3N2BR
SAS Label:: Influenza A/H3N2 virus B/Brisban/60/2008
English Text:: Titer against influenza A/H3N2 virus B/Brisbane/60/2008
Target:: Both males and females 0 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
5 to 640	Range of Values	3330	3330
.	Missing	0	3330

WTSFM10 - 2010 one year MEC weights

Variable Name:: WTSFM10
SAS Label:: 2010 one year MEC weights
English Text:: 2010 one year MEC weights
Target:: Both males and females 0 YEARS - 150 YEARS

Code or Value	Value Description	Count	Cumulative	Skip to Item
11001.258973 to 332614.354496	Range of Values	3330	3330
.	Missing	0	3330

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