The adverse impact on quality of life and sizable cost of WTC-lung injury (WTC-LI) are public health concerns. We propose to Identify and Validate metabolic contributors of WTC-LI through comprehensive metabolomics profiling and integration of relevant clinical, environmental, and serum biomarkers. We propose to investigate targeted behavioral dietary modification to alter modifiable risk factors and metabolomic (scientific study of chemical processes involving metabolites) biomarkers that may mitigate disease severity and improve the health and well-being of WTC exposed patients.
Haider SH, Kwon S, Lam R, et al. 2018. Predictive Biomarkers of Gastroesophageal Reflux Disease and Barrett’s Esophagus in World Trade Center Exposed Firefighters: A 15 Year Longitudinal Study. Scientific Reports, 8 (1), art. no. 3106.
Crowley G, Kwon S, Haider SH, et al. 2018. Metabolomics of World Trade Center-Lung Inju-ry: a machine learning approach. BMJ Open Respiratory Research. 5(1):e000274.
