Environmental toxins exert damaging health effects in workers. Volunteers of the World Trade Center (WTC) rescue and recovery effort following WTC attacks may be at increased risk for worsening health. The goal of this proposal is to quantify the risk of kidney damage among first responders to the WTC attack and determine its relationship to particulate matter exposure. We hypothesize that exposure to inhaled particulate matter causes systemic inflammation and endothelial dysfunction that result in chronic kidney and cardiovascular damage. Knowledge to be gained from this proposal can influence strategies to minimize the risk of chronic kidney and cardiovascular disease among first responders.
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