Gene Expression Profiles as Markers of PTSD Risk and Resilience in WTC Responders

Project Number
Icahn School of Medicine at Mount Sinai
Fiscal Year Awarded
Project Duration
1 year


Post-traumatic stress disorder (PTSD) arising in response to the World Trade Center (WTC) disaster is one of the most prevalent and persistent psychiatric disorders among workers involved in rescue, recovery, and clean-up efforts, even over a decade after 9/11. This study involves a comprehensive, multi-modal, and integrative assessment of biomarkers implicated in the pathophysiology of PTSD, including measuring differences in whole-blood gene expression and other blood biomarkers of key neurobiological systems, an approach critical to informing risk and resilience prediction algorithms for PTSD, and to develop novel psychopharmacologic approaches for the treatment of this disabling condition in disaster responders and other trauma survivors.


No publications available at this time.

Image of Adriana  Feder, MD
Principal Investigator: Adriana Feder, MD
Icahn School of Medicine at Mount Sinai