Public Health Statement for Bromoform and Dibromochloromethane
Spanish: Bromoformo y Dibromoclorometano
CAS#: 75-25-2; 124-48-1
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This Public Health Statement is the summary chapter from the Toxicological Profile for Bromoform and Dibromochloromethane. It is
one in a series of Public Health Statements about hazardous substances and their health effects. A shorter version, the ToxFAQs, is also available. This information is important because this substance may harm you. The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present. For more information, call the ATSDR Information Center at 1-888-422-8737.
This public health statement tells you about bromoform and dibromochloromethane and the effects of exposure to them.
The Environmental Protection Agency (EPA) identifies the most serious hazardous waste sites in the nation. These sites are then placed on the National Priorities List (NPL) and are targeted for long-term federal clean-up activities. Bromoform and dibromochloromethane has been found in at least 140 and 174 of the 1,662 current or former NPL sites. Although the total number of NPL sites evaluated for these substances is not known, the possibility exists that the number of sites at which bromoform and dibromochloromethane is found may increase in the future as more sites are evaluated. This information is important because these sites may be sources of exposure and exposure to these substances may harm you.
When a substance is released either from a large area, such as an industrial plant, or from a container, such as a drum or bottle, it enters the environment. Such a release does not always lead to exposure.
You can be exposed to a substance only when you come in contact with it. You may be exposed by breathing, eating, or drinking the substance, or by skin contact.
If you are exposed to bromoform or dichlorobromomethane, many factors will determine whether you will be harmed. These factors include the dose (how much), the duration (how long), and how you come in contact with them. You must also consider any other chemicals you are exposed to and your age, sex, diet, family traits, lifestyle, and state of health.
What are bromoform and dibromochloromethane?
Bromoform (also known as tribromomethane) and dibromochloromethane are colorless to yellow, heavy, nonburnable liquids with a sweetish odor. These chemicals are possible contaminants of drinking water that has been chlorinated to kill bacteria and viruses that could cause serious waterborne infectious diseases. Bromoform and dibromochloromethane may form when chlorine reacts with other naturally occurring substances in water, such as decomposing plant material. Plants in the ocean also produce small amounts of these chemicals.
These chemicals are found mainly in water that originally came from surface sources, such as rivers and lakes. Springs and deep drilled wells usually contain very little of the substances that react with chlorine to form these chemicals; therefore, well and spring water is less likely a source of bromoform and dibromochloromethane than water from a reservoir (artificial lake). The amount of bromoform and dibromochloromethane in drinking water can change considerably from day to day, depending on the source, temperature, amount of plant material in the water, amount of chlorine added, and a variety of other factors.
In the past, bromoform was used by industry to dissolve dirt and grease and to make other chemicals. It was also used in the early part of this century as a medicine to help children with whooping cough get to sleep. Currently, bromoform is only produced in small amounts for use in laboratories and in geological and electronics testing. Dibromochloromethane was used in the past to make other chemicals such as fire extinguisher fluids, spray can propellants, refrigerator fluid, and pesticides. It is now only used on a small scale in laboratories.
In the environment, bromoform and dibromochloromethane are not found as pure liquids, but instead, they are found either dissolved in water or evaporated into air as a gas. Both bromoform and dibromochloromethane are relatively stable in the air, but reactions with other chemicals in the air cause them to break down slowly (about 50% in 1 or 2 months). Bromoform and dibromochloromethane in water or soil may also be broken down by bacteria, but the speed of this process is not known.
What happens to bromoform and dibromochloromethane when they
enter the environment?
Bromoform and dibromochloromethane enter
the environment through the disposal of water that has been
disinfected with chlorine or as vapors emitted from chlorinated
water. These chemicals are also made naturally by plant-like
organisms called algae that are found in the oceans. Some
part of bromoform and dibromochloromethane that enters the
air is removed by rain. What is left in the air takes about
1-2 months for half of it to degrade. In water, bromoform
and dibromochloromethane are slowly broken down at the water
surface where oxygen is available, but break down much faster
in deep water and in water that is underground where there
is a lot less oxygen. Bromoform and dibromochloromethane are
mobile in soils and may seep into groundwater. Bromoform and
dibromochloromethane do not appear to concentrate in fish.
How might I be exposed to bromoform and dibromochloromethane?
You are most likely to be exposed to
bromoform and dibromochloromethane by drinking water that
has been treated with chlorine. Usually, the levels in chlorinated
drinking water are between 1 and 10 parts of bromoform and
dibromochloromethane per billion parts of water (ppb). These
are levels that are known to be without adverse health effects.
Bromoform and dibromochloromethane have also been detected
in chlorinated swimming pools.
Exposure can occur at a swimming pool,
by breathing bromoform or dibromochloromethane that has evaporated
into the air, or by uptake from the water through the skin.
Neither dibromochloromethane nor bromoform are likely to be
found in food.
If you live near a factory or laboratory
that makes or uses dibromochloromethane or bromoform, you
might be exposed to dibromochloromethane or bromoform in the
air. Currently, bromoform is only used for geological and
electronics testing. Dibromochloromethane is used on a small-scale
in laboratories. Since neither dibromochloromethane nor bromoform
have widespread use in this country, they are usually present
in outside air at very low levels (less than 0.01 ppb). Therefore,
exposure to bromoform or dibromochloromethane in the air is
a minor route. Exposure may occur if you come into contact
with water or soil at a chemical waste site where dibromochloromethane
or bromoform has been disposed.
How can bromoform and dibromochloromethane enter and leave my
body?
Studies in animals or humans indicate
that both bromoform and dibromochloromethane can easily enter
your body after swallowing them in water or breathing them
in air. They can also enter your body through your skin (for
example, by washing or showering in water containing these
chemicals). Some portion of bromoform and dibromochloromethane
entering your body may be broken down to other compounds.
Bromoform, dibromochloromethane, and their breakdown products
can be removed from the body by being exhaled from the lungs.
These chemicals leave the body fairly rapidly. Bromoform and
dibromochloromethane do not tend to build up in the body, 50-90%
of the amount that enters the body is removed within 8 hours.
How can bromoform and dibromochloromethane affect my health?
Scientists use many tests to protect
the public from harmful effects of toxic chemicals and to
find ways for treating persons who have been harmed.
One way to learn whether a chemical will
harm people is to determine how the body absorbs, uses, and
releases the chemical. For some chemicals, animal testing
may be necessary. Animal testing may also help identify health
effects such as cancer or birth defects. Without laboratory
animals, scientists would lose a basic method for getting
information needed to make wise decisions that protect public
health. Scientists have the responsibility to treat research
animals with care and compassion. Scientists must comply with
strict animal care guidelines because laws today protect the
welfare of research animals.
The effects of bromoform and dibromochloromethane
on your health depend largely on the amount you take into
your body and the duration of exposure. In general, the more
you take in, the greater the chance that an effect will occur.
The main effect of swallowing or breathing large amounts of
bromoform is a slowing of normal brain activities, resulting
in sleepiness or sedation occuring quickly after the chemicals
enter your body. In humans, these effects tend to disappear
within a day. Exposures capable of producing these effects
include swallowing 1-4 drops of liquid bromoform, an amount
much greater than is usually found in a glass of drinking
water. At much higher amounts, a person may become unconsciousness
or die. The amount of dibromochloromethane taken by mouth
that would affect humans is not known, but is probably similar
to bromoform.
Some studies in animals indicate that
exposure to high doses of bromoform or dibromochloromethane
may also lead to liver and the kidney injury within a short
period of time. Exposure to low levels of bromoform or dibromochloromethane
do not appear to seriously affect the brain, liver, or kidneys.
Other animal studies suggest that typical bromoform or dibromochloromethane
exposures do not pose a high risk of affecting the chance
of becoming pregnant or harming an unborn baby. However, studies
in animals indicate that long-term intake of either bromoform
or dibromochloromethane can cause liver and kidney cancer.
Although cancer in humans cannot be definitely attributed
to these chemicals, it is an effect of special concern, since
many people are exposed to low levels of bromoform and dibromochloromethane
in chlorinated drinking water.
The International Agency for Research
on Cancer (IARC) concluded that bromoform and dibromochloromethane
are not classifiable as to human carcinogenicity. The EPA
classified bromoform as a probable human carcinogen and dibromochloromethane
as a possible human carcinogen.
How can bromoform and dibromochloromethane affect children?
This section discusses potential health
effects in humans from exposures during the period from conception
to maturity at 18 years of age.
In the early 1900s, bromoform was given
to children suffering from whooping cough, resulting in several
deaths when children were accidentally overdosed. Children
appeared drowsy, then lifeless, just before dying.
There are no studies in humans or laboratory
animals that examine whether the effects of bromoform and
dibromochloromethane change with age. Based on current knowledge
of body function, and metabolism in the body, there is no
indication that children will be affected more than adults.
How can families reduce the risk of exposure to bromoform and
dibromochloromethane?
If your doctor finds that you have been
exposed to substantial amounts of bromoform and/or dibromochloromethane,
ask whether your children might also have been exposed. Your
doctor might need to ask your state health department to investigate.
The chance of consuming bromoform or
dibromochloromethane in chlorinated public drinking water
varies with season, water temperature, water chemistry, disinfection
method, and other factors. However, the health risks associated
with drinking non-disinfected water when there is evidence
of disease-causing contamination (i.e., bacteria, viruses,
etc.) are much greater than the risk of adverse health effects
from exposure to bromoform or dibromochloromethane.
There are water treatment methods that
people can be used in the home to reduce exposure to bromoform
and dibromochloromethane from chlorinated tap water. These
include simple do-it-yourself methods such as connecting solid
carbon black filters to faucets and shower taps. Homeowners
may discuss other home water treatment methods, including
filtering, aeration or boiling, distillation, and/or activated
charcoal, with a professional plumber or water well contractor.
The chance of exposure to bromoform and dibromochloromethane
may be reduced by minimizing contact with water expected to
have higher levels of these chemicals, such as chlorinated
swimming pool water. When bathing or showering some portion
of dibromochloromethane and/or bromoform may evaporate into
the air. Opening bathroom windows, and taking shorter baths
and showers may reduce the amount of chemical vapor that is
inhaled or absorbed through the skin.
Is there a medical test to determine whether i have been exposed
to bromoform and dibromochloromethane?
If you are exposed to bromoform
or dibromochloromethane, measurable levels of the chemicals
can sometimes be detected in samples of your blood, breath,
or fat. However, there is not enough information at present
to use the results of such tests to estimate the level of exposure
or to predict the nature or the severity of any health effects
that might result. Since special equipment is needed, these
tests are not routinely performed in doctors' offices. Because
bromoform and dibromochloromethane are quickly eliminated from
the body, these special laboratory tests are only effective
in detecting recent exposures (within 1 or 2 days).
What recommendations has the federal
government made to protect human health?
The federal government develops regulations
and recommendations to protect public health. Regulations
can be enforced by law. The EPA, the Occupational Safety and
Health Administration (OSHA), and the Food and Drug Administration
(FDA) are some federal agencies that develop regulations for
toxic substances. Recommendations provide valuable guidelines
to protect public health, but cannot be enforced by law. The
Agency for Toxic Substances and Disease Registry (ATSDR) and
the National Institute for Occupational Safety and Health
(NIOSH) are two federal organizations that develop recommendations
for toxic substances.
Regulations and recommendations can be
expressed as "not-to-exceed" levels, that is, levels
of a toxic substance in air, water, soil, or food that do
not exceed a critical value that is usually based on levels
that affect animals; they are then adjusted to levels that
will help protect humans. Sometimes these not-to-exceed levels
differ among federal organizations because they used different
exposure times (an 8-hour workday or a 24-hour day), different
animal studies, or other factors.
Recommendations and regulations are also
updated periodically as more information becomes available.
For the most current information, check with the federal agency
or organization that provides it. Some regulations and recommendations
for bromoform and dibromochloromethane include the following:
OSHA has set a legally enforceable limit
of 0.5 ppm for bromoform in workroom air to protect workers
during an 8-hour shift over a 40-hour work week.
EPA recommends that drinking water levels
for bromoform should not be more than 0.7 parts per million
(ppm) for bromoform and 0.7 ppm for dibromochloromethane.
References
Agency for Toxic Substances and Disease Registry (ATSDR). 2005. Toxicological profile for Bromoform and Chlorodibromomethane. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
Where can I get more information?
If you have questions or concerns, please contact your community or state health or environmental quality department or:
For more information, contact:
Agency for Toxic Substances and Disease Registry
Division of Toxicology and Human Health Sciences
4770 Buford Highway
Chamblee, GA 30341-3717
Phone: 1-800-CDC-INFO 888-232-6348 (TTY)
Email: Contact CDC-INFO
ATSDR can also tell you the location of occupational and environmental health clinics. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances.