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Work-related asthma: Most frequently reported agents associated with work-related asthma cases by state, 2009–2012

AOEC1MW3CaliforniaMassachusettsMichiganNew YorkTotal
CodeAgentA2NumberPercentNumberPercentNumberPercentNumberPercentNumberPercent
Miscellaneous chemicals and materials 529 21.3 40 25.2 61 17.4 216 27.4 846 22.4
320.06 Chemicals, n.o.s. U 263 10.6 1 0.6 15 4.3 42 5.3 321 8.5
320.23 Perfume, n.o.s. U 87 3.5 15 9.4 11 3.1 15 1.9 128 3.4
320.39 World Trade Center pollution U 121 15.4 121 3.2
320.16 Pesticides, n.o.s. U 29 1.2 2 1.3 4 1.1 4 0.5 39 1.0
320.110 Glues, n.o.s. U 26 1.0 2 1.3 5 1.4 1 0.1 34 0.9
320.100 Fire extinguisher discharge U 17 0.7 1 0.6 4 1.1 7 0.9 29 0.8
320.15 Odors U 22 0.9 2 1.3 4 0.5 28 0.7
320.42 Air freshener U 17 0.7 4 2.5 2 0.6 1 0.1 24 0.6
320.450 Insecticides, n.o.s. U 15 0.6 15 0.4
321.00 Pharmaceuticals, n.o.s. U 10 0.4 1 0.3 1 0.1 12 0.3
320.28 Cosmetics, n.o.s. U 5 0.2 1 0.6 2 0.6 8 0.2
323.03 Sewer water U 3 0.1 1 0.6 3 0.9 1 0.1 8 0.2
320.35 Carpet dust U 4 0.2 1 0.6 2 0.3 7 0.2
320.13 Herbicides, n.o.s. U 5 0.2 1 0.1 6 0.2
324.05 Pancreatin A U 6 0.8 6 0.2
320.27 Mace L 4 0.2 1 0.1 5 0.1
327.00 Water contamination, n.o.s.; hot tub fumes, n.o.s. U 5 3.1 5 0.1
All others within this exposure category4 22 0.9 5 3.1 14 4.0 9 1.1 50 1.3
Mineral and inorganic dusts 329 13.3 38 23.9 38 10.9 210 26.7 615 16.3
010.00 Dust, n.o.s. U 258 10.4 25 15.7 20 5.7 191 24.3 494 13.1
010.03 Cement dust U 22 0.9 2 1.3 3 0.9 2 0.3 29 0.8
010.091 Fiberglass U 13 0.5 4 2.5 5 1.4 5 0.6 27 0.7
010.020 Asbestos, n.o.s. U 14 0.6 2 1.3 2 0.6 4 0.5 22 0.6
010.040 Toner, copier U 6 0.2 1 0.3 7 0.2
010.133 Silica, crystalline L 1 0.04 2 1.3 3 0.4 6 0.2
All others within this exposure category4 15 0.6 3 1.9 7 2.0 5 0.6 30 0.8
Cleaning materials 291 11.7 58 36.5 119 34.0 109 13.9 577 15.3
322.00 Cleaning materials, n.o.s. U 118 4.8 6 3.8 23 6.6 17 2.2 164 4.3
322.10 Sodium hypochlorite A L 43 1.7 9 5.7 20 5.7 19 2.4 91 2.4
322.19 Cleaners, disinfectant, n.o.s. U 16 0.6 6 3.8 13 3.7 20 2.5 55 1.5
322.21 Cleaners, floor stripping U 17 0.7 10 6.3 17 4.9 11 1.4 55 1.5
322.35 Floor wax U 24 1.0 5 3.1 12 3.4 14 1.8 55 1.5
322.16 Cleaners, carpet U 15 0.6 1 0.6 2 0.6 5 0.6 23 0.6
322.31 Cleaning mixtures (excluding bleach plus acid or ammonia) U 1 0.04 1 0.6 18 5.1 20 0.5
322.07 Ammonium hydroxide, n.o.s. A L 12 0.5 4 1.1 3 0.4 19 0.5
322.18 Cleaners, detergent, n.o.s. U 4 0.2 1 0.3 4 0.5 9 0.2
322.25 Cleaners, oven U 6 0.2 1 0.6 1 0.3 1 0.1 9 0.2
322.28 Cleaners, toilet bowl U 6 0.2 1 0.6 1 0.1 8 0.2
322.11 Bleach plus acid (mixture) U 6 0.2 1 0.6 7 0.2
322.320 Quaternary ammonium compounds, n.o.s. L 3 0.1 2 0.6 2 0.3 7 0.2
322.12 Bleach plus ammonia (mixture) U 2 0.1 4 0.5 6 0.2
322.326 Alkyl dimethyl benzyl ammonium chloride A L 2 0.1 2 0.6 2 0.3 6 0.2
322.06 Cleaners, solvent-based U 2 0.1 2 1.3 1 0.1 5 0.1
322.323 Didecyl dimethyl ammonium chloride A L 1 0.04 3 1.9 1 0.1 5 0.1
All others within this exposure category4 13 0.5 12 7.5 4 1.1 4 0.5 33 0.9
Pyrolysis products 279 11.3 21 13.2 35 10.0 102 13.0 437 11.6
330.03 Smoke, n.o.s. U 179 7.2 15 9.4 20 5.7 72 9.1 286 7.6
330.01 Cigarette smoke U 49 2.0 3 1.9 3 0.9 4 0.5 59 1.6
331.01 Diesel exhaust U 21 0.8 1 0.6 9 2.6 11 1.4 42 1.1
331.00 Exhaust, n.o.s. U 19 0.8 1 0.3 3 0.4 23 0.6
330.02 Plastic smoke U 3 0.1 2 1.3 1 0.3 9 1.1 15 0.4
331.03 Jet exhaust U 4 0.2 3 0.4 7 0.2
All others within this exposure category4 4 0.2 1 0.3 5 0.1
Indoor air pollutants 269 10.9 22 13.8 39 11.1 27 3.4 357 9.5
320.01 Air pollutants, indoor U 157 6.3 10 6.3 20 5.7 9 1.1 196 5.2
320.33 Indoor air pollutants from building renovation U 112 4.5 12 7.5 19 5.4 18 2.3 161 4.3
Mold 152 6.1 27 17.0 31 8.9 53 6.7 263 7.0
391.01 Mold, n.o.s. H 149 6.0 26 16.4 31 8.9 52 6.6 258 6.8
All others within this exposure category4 3 0.1 1 0.6 1 0.1 5 0.1
Plant/Tree material 132 5.3 14 8.8 18 5.1 34 4.3 198 5.2
370.35 Capsicum L 35 1.4 2 1.3 1 0.3 13 1.7 51 1.4
370.004 Plant material, n.o.s. U 28 1.1 1 0.6 1 0.3 30 0.8
373.00 Wood dust, n.o.s. L 14 0.6 3 1.9 4 1.1 5 0.6 26 0.7
370.10 Pollen H 15 0.6 2 1.3 2 0.6 3 0.4 22 0.6
371.00 Flour, n.o.s. A H 7 0.3 2 1.3 6 1.7 4 0.5 19 0.5
370.010 Paper dust U 8 0.3 2 1.3 2 0.3 12 0.3
370.07 Grass cuttings H 7 0.3 1 0.3 1 0.1 9 0.2
370.08 Hay H 4 0.2 4 0.5 8 0.2
All others within this exposure category4 14 0.6 2 1.3 3 0.9 2 0.3 21 0.6
Ergonomics 111 4.5 7 4.4 55 7.0 173 4.6
360.06 Exercise N/A 49 2.0 5 3.1 41 5.2 95 2.5
360.04 Stress N/A 62 2.5 1 0.6 14 1.8 77 2.0
All others within this exposure category4 1 0.6 1 0.03
Solvents, n.o.s. 79 3.2 4 2.5 23 6.6 32 4.1 138 3.7
171.01 Paint, n.o.s. U 56 2.3 4 2.5 18 5.1 20 2.5 98 2.6
171.00 Solvents, n.o.s. U 11 0.4 3 0.9 6 0.8 20 0.5
171.07 Lacquer U 6 0.2 1 0.3 3 0.4 10 0.3
All others within this exposure category4 U 6 0.2 1 0.3 3 0.4 10 0.3
Animal/Insect material 75 3.0 15 9.4 13 3.7 8 1.0 111 2.9
380.14 Mice A H 12 0.5 1 0.6 3 0.9 16 0.4
380.00 Animal material, n.o.s. H 8 0.3 1 0.6 4 1.1 2 0.3 15 0.4
380.22 Cat A H 9 0.4 3 1.9 2 0.6 1 0.1 15 0.4
380.18 Rat antigens A H 6 0.2 3 1.9 1 0.3 10 0.3
380.040 Animal dander, n.o.s. H 4 0.2 2 1.3 3 0.4 9 0.2
382.00 Insect, n.o.s. H 7 0.3 2 1.3 9 0.2
380.20 Rat feces H 6 0.2 1 0.6 7 0.2
380.01 Animal antigens H 6 0.2 6 0.2
380.05 Venom U 5 0.2 5 0.1
All others within this exposure category4 12 0.5 2 1.3 3 0.9 2 0.3 19 0.5
Acids, bases and oxidizing agents 48 1.9 4 2.5 23 6.6 23 2.9 98 2.6
050.24 Sulfuric acid A L 13 0.5 1 0.6 2 0.6 1 0.1 17 0.5
050.10 Hydrochloric acid A L 7 0.3 8 2.3 1 0.1 16 0.4
052.011 Anhydrous ammonia A L 13 0.5 1 0.1 14 0.4
050.00 Acids, bases, oxidizers, n.o.s. L 5 0.2 1 0.6 5 1.4 1 0.1 12 0.3
050.28 Disinfectants, n.o.s. L 2 0.1 1 0.6 4 0.5 7 0.2
050.13 Nitric acid L 1 0.04 1 0.3 3 0.4 5 0.1
050.15 Phosphoric acid L 1 0.04 1 0.6 3 0.4 5 0.1
All others within this exposure category4 6 0.2 7 2.0 9 1.1 22 0.6
Aliphatic and alicyclic hydrocarbons 54 2.2 3 1.9 11 3.1 18 2.3 86 2.3
061.07 Asphalt L 11 0.4 2 0.6 9 1.1 22 0.6
060.11 4-Phenylcyclohexene L 17 0.7 2 1.3 19 0.5
060.080 Natural gas L 8 0.3 1 0.1 9 0.2
061.060 Diesel fuel L 4 0.2 1 0.3 3 0.4 8 0.2
All others within this exposure category4 14 0.6 1 0.6 8 2.3 5 0.6 28 0.7
Metals and metalloids 38 1.5 6 3.8 22 6.3 19 2.4 85 2.3
023.000 Welding fume, n.o.s. U 8 0.3 12 3.4 2 0.3 22 0.6
021.00 Metal dust, n.o.s. U 7 0.3 4 1.1 3 0.4 14 0.4
023.10 Soldering, n.o.s. U 4 0.2 1 0.6 2 0.3 7 0.2
All others within this exposure category4 19 0.8 5 3.1 6 1.7 12 1.5 42 1.1
Physical factors 41 1.7 7 4.4 5 1.4 25 3.2 78 2.1
350.02 Cold N/A 25 1.0 3 1.9 2 0.6 6 0.8 36 1.0
350.03 Heat N/A 10 0.4 2 1.3 1 0.3 7 0.9 20 0.5
353.12 Assault, physical N/A 10 1.3 10 0.3
350.05 Humidity, high N/A 2 0.1 2 1.3 1 0.1 5 0.1
All others within this exposure category4 4 0.2 2 0.6 1 0.1 7 0.2
Aldehydes and acetals 22 0.9 7 4.4 14 4.0 8 1.0 51 1.4
120.03 Formaldehyde A L 9 0.4 4 2.5 11 3.1 8 1.0 32 0.8
120.051 Glutaraldehyde A L 11 0.4 2 1.3 1 0.3 14 0.4
All others within this exposure category4 2 0.1 1 0.6 2 0.6 5 0.1
Halogens (inorganic) 28 1.1 2 1.3 13 3.7 2 0.3 45 1.2
030.02 Chlorine A L 21 0.8 11 3.1 1 0.1 33 0.9
030.06 Chlorine dioxide L 4 0.2 1 0.1 5 0.1
All others within this exposure category4 3 0.1 2 1.3 2 0.6 7 0.2
Miscellaneous inorganic compounds 25 1.0 1 0.6 5 1.4 9 1.1 40 1.1
040.06 Hydrogen sulfide L 6 0.2 1 0.6 2 0.3 9 0.2
040.04 Carbon monoxide L 7 0.3 1 0.1 8 0.2
040.201 Sulfur dioxide L 5 0.2 2 0.6 7 0.2
All others within this exposure category4 7 0.3 3 0.9 6 0.8 16 0.4
Hydrocarbons, n.o.s. 9 0.4 2 1.3 19 5.4 9 1.1 39 1.0
170.01 Cutting oils A U 1 0.04 14 4.0 6 0.8 21 0.6
170.00 Hydrocarbons, n.o.s. U 3 0.1 1 0.6 3 0.4 7 0.2
All others within this exposure category4 5 0.2 1 0.6 5 1.4 11 0.3
Isocyanates 7 0.3 4 2.5 22 6.3 3 0.4 36 1.0
221.00 Diisocyanates, n.o.s. A L 5 0.2 2 1.3 9 2.6 2 0.3 18 0.5
221.02 Methylene bisphenyl diisocyanate A L 1 0.6 6 1.7 1 0.1 8 0.2
221.01 Toluene diisocyanate L 1 0.04 1 0.6 3 0.9 5 0.1
All others within this exposure category4 1 0.04 4 1.1 5 0.1
Polymers 11 0.4 5 3.1 9 2.6 2 0.3 27 0.7
270.02 Natural rubber latex A H 5 0.2 3 0.9 1 0.1 9 0.2
270.079 Polyurethane L 1 0.04 1 0.6 3 0.9 5 0.1
All others within this exposure category4 5 0.2 4 2.5 3 0.9 1 0.1 13 0.3
Microorganisms, not including mold 22 0.9 1 0.6 1 0.3 24 0.6
390.00 Microorganisms, n.o.s. U 18 0.7 18 0.5
All others within this exposure category4 4 0.2 1 0.6 1 0.3 6 0.2
Ketones 7 0.3 2 1.3 4 1.1 4 0.5 17 0.5
130.01 Acetone L 6 0.2 2 1.3 3 0.9 2 0.3 13 0.3
All others within this exposure category4 1 0.04 1 0.3 2 0.3 4 0.1
Alcohols 10 0.4 4 2.5 1 0.3 1 0.1 16 0.4
070.06 Isopropyl alcohol L 5 0.2 1 0.6 1 0.3 7 0.2
070.05 Ethanol L 3 0.1 2 1.3 1 0.1 6 0.2
All others within this exposure category4 2 0.1 1 0.6 3 0.1
Epoxy compounds 7 0.3 4 2.5 3 0.9 2 0.3 16 0.4
110.02 Epoxy resins A L 6 0.2 4 2.5 3 0.9 13 0.3
All others within this exposure category4 1 0.04 2 0.3 3 0.1
Hydrocarbons 6 0.2 1 0.6 3 0.9 4 0.5 14 0.4
Halogenated aliphatic hydrocarbons 6 0.2 2 1.3 6 0.8 14 0.4
Aliphatic and alicyclic amines 1 0.04 5 3.1 2 0.3 8 0.2
Glycol ethers 3 0.1 1 0.6 2 0.3 6 0.2
Phenols and phenolic compounds 3 0.1 1 0.3 2 0.3 6 0.2
Aromatic nitro and amino compounds 2 0.1 1 0.6 2 0.6 1 0.1 6 0.2
Organophosphate pesticides/carbamate pesticides 1 0.6 2 0.6 3 0.4 6 0.2
292.00 Carbamate pesticides, n.o.s. L 2 0.6 3 0.4 5 0.1
All others within this exposure category4 1 0.6 1 0.03
Aliphatic carboxylic acids and anhydrides 3 1.9 2 0.6 5 0.1
All other exposure categories5 7 0.3 1 0.6 2 0.6 6 0.8 16 0.4
000.00 Hazard not on file 558 22.5 2 1.3 1 0.3 1 0.1 562 14.9

– indicates no cases.    n.o.s. - not otherwise specified
1 Association of Occupational and Environmental Clinics (AOEC) exposure categories, exposure codes, and agents as of April 2016. See AOEC exposure code lookup for more information.
2 Substances designated as asthma causing agents by the AOEC as of April 2016.
3 MW - molecular weight, L - low molecular weight (less than 10,000 Daltons), H - high molecular weight (greater than or equal to 10,000 Daltons), U - unable to classify molecular weight, and N/A - not applicable. High and low molecular weight designations presented are not meant to serve as a definitive source of molecular weights for reported agents.
4 "All others within this exposure category" includes exposures associated with less than 5 cases.
5 "All other exposure categories" includes overall categories with less than 5 cases reported. This includes glycols (n=4), cyanides and nitriles (n=2), esters (n=3), ethers (n=2), halogenated aromatic hydrocarbons (n=3), aliphatic and miscellaneous nitrogen compounds (n=1), and organic sulfur compounds (n=1).

Note:

Each case was associated with up to three putative agents.

Percentages for each state are based on the number of cases reported from California (n=2,478), Massachusetts (n=159), Michigan (n=350), New York (n=787).

See Appendix for more information.

Source:

Sentinel surveillance data as of June 2017, reported by R. Harrison, J. Flattery, J. Weinberg (California); L. Davis, E. Pechter, and K. Fitzsimmons (Massachusetts); K. Rosenman, MJ. Reilly, and B. Pickelman (Michigan); and K. Gelberg and K. Cummings (New York).

Citation:

NIOSH 2017. Work-Related Lung Disease Surveillance System (eWoRLD). 2017-926 U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Respiratory Health Division, Morgantown, WV. Available at: <https://wwwn.cdc.gov/eworld/Data/926> October 23, 2017.

Reference Number: 2017-926

Date Posted: July 2017

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