|Molecular Weight of Agent||LMW|
|Occupation|| Not specified|
|Outcome/Diagnosis||Isocyanate-induced occupational asthma.|
|Activity Intervention|| Removal from exposure to isocyanates(approximately 2 years).|
|Participation Rate||79 of 89 (89%) subjects with isocyanate-induced occupational asthma.|
|Intervention Effectiveness||Results between the time of diagnosis (T0) and 2 years after their removal from exposure(T2):
1.There was no statistical significant difference for spirometry data and antiasthmatic medication use (P=0.11)
2. There were 73% and 39% of patients still using short-acting beta2 agonists and inhaling glucocorticoids, respectively at T2.
3. 31 (40%) subjects had a forced expiratory volume in 1 second variation of +/- 10%.
4. Forced expiratory volume improved in 14 (18%) subjects.
5. Nonspecific bronchial hyper-responsiveness improved in 19 (24%) subjects.
6. 4 (5%) subjects had clinical remission.
7. The mean impairment-disability score was 21%+/- 13% at T2 according to the scale used by the Workers’ Compensation Board.