Prevention of Work-related Asthma: Study Search

Prevention LevelSecondary
Study Year2006
Molecular Weight of AgentLMW
Agent CategoryDiisocyanates
Specific AgentIsocyanates
Occupation Not specified
Outcome/DiagnosisIsocyanate-induced occupational asthma.
Activity Intervention Removal from exposure to isocyanates(approximately 2 years).
Participation Rate79 of 89 (89%) subjects with isocyanate-induced occupational asthma.
Intervention EffectivenessResults between the time of diagnosis (T0) and 2 years after their removal from exposure(T2): 1.There was no statistical significant difference for spirometry data and antiasthmatic medication use (P=0.11) 2. There were 73% and 39% of patients still using short-acting beta2 agonists and inhaling glucocorticoids, respectively at T2. 3. 31 (40%) subjects had a forced expiratory volume in 1 second variation of +/- 10%. 4. Forced expiratory volume improved in 14 (18%) subjects. 5. Nonspecific bronchial hyper-responsiveness improved in 19 (24%) subjects. 6. 4 (5%) subjects had clinical remission. 7. The mean impairment-disability score was 21%+/- 13% at T2 according to the scale used by the Workers’ Compensation Board.
Page last reviewed: February 20, 2020