|Molecular Weight of Agent||LMW|
|Occupation|| Various occupations (Workers exposed to diisocyanates)|
|Outcome/Diagnosis||Diisocyanate-induced occupational asthma (DiOA)|
|Activity Intervention|| Medical surveillance program (MSP) for diisocyanate-induced occupational asthma.|
|Participation Rate||2897 workers answered the surveillance questionnaire (participation rate: 90%).|
|Intervention Effectiveness||20 workers (0.69% of 2897) with final diagnosis of DiOA in MSP (screened group) compared with 66 workers diagnosed with DiOA without participation in MSP (control group).
Two years after diagnosis and removal from exposure:
The 20 subjects had a mean PC20 of 4.81 mg/ml significant higher than a mean PC20 of 1.67 mg/ml for control group.
Clinical remission defined by a PC20 > 8 mg/ml and no anti-asthma medication was 34% for screened group significant different with 16% for control group.
The median costs of compensation for functional impairment were significant lower with $C11893 in the screened group compared with $C19562 for the control group.