Prevention of Work-related Asthma: Study Search

Prevention LevelSecondary
AuthorLabrecque M
Study Year2011
CountryCanada
Molecular Weight of AgentLMW
Agent CategoryDiisocyanates
Specific AgentDiisocyanates
Occupation Various occupations (Workers exposed to diisocyanates)
Outcome/DiagnosisDiisocyanate-induced occupational asthma (DiOA)
Activity Intervention Medical surveillance program (MSP) for diisocyanate-induced occupational asthma.
Participation Rate2897 workers answered the surveillance questionnaire (participation rate: 90%).
Intervention Effectiveness20 workers (0.69% of 2897) with final diagnosis of DiOA in MSP (screened group) compared with 66 workers diagnosed with DiOA without participation in MSP (control group). Two years after diagnosis and removal from exposure:
  • The 20 subjects had a mean PC20 of 4.81 mg/ml significant higher than a mean PC20 of 1.67 mg/ml for control group.
  • Clinical remission defined by a PC20 > 8 mg/ml and no anti-asthma medication was 34% for screened group significant different with 16% for control group.
  • The median costs of compensation for functional impairment were significant lower with $C11893 in the screened group compared with $C19562 for the control group.
    Page last reviewed: February 20, 2020