Prevention of Work-related Asthma: Study Search

Prevention LevelSecondary
AuthorTalini D
Study Year2012
CountryItaly
Molecular Weight of AgentBoth
Agent CategoryVarious
Specific AgentLatex, diisocyanates, hairdressing products, wood and flour dusts
Occupation Not specified
Outcome/DiagnosisOccupational asthma
Activity Intervention Reduction of occupational exposure to specific sensitizers or cessation of work (at least 6 months)
Participation Rate41 subjects with occupational asthma were included in this follow-up study
Intervention EffectivenessAmong these 41 subjects, ten were in the same workplace, twenty two had reduced exposure, and nine had ceased to work for at least 6 months before the follow-up examination. For reduction of exposure (n=22): follow-up vs diagnosis • Presence of asthma symptoms: 41% vs 95.3% • PD20FEV1, ug: 374.7 vs 168.5* For cessation of work (n=9): follow-up vs diagnosis • Presence of asthma symptoms: 42.6% vs 78.3% • PD20FEV1, ug: 250.7 vs 173.2** • Improvement in sputum eosinophilia** Shorter duration of exposure at diagnosis predicted increase in PD20FEV1 at follow-up (p<0.05). PD20 ratio (PD20FEV1 methacholine at follow-up and at diagnosis) was 8.1 ± 11.9 and 1.1 ± 0.9 for reduced and continued exposures, respectively, and this difference was statistically significant (p=0.03). *P<0.05. **0.05
Page last reviewed: February 20, 2020