|Molecular Weight of Agent||Both|
|Specific Agent||Latex, diisocyanates, hairdressing products, wood and flour dusts|
|Occupation|| Not specified|
|Activity Intervention|| Reduction of occupational exposure to specific sensitizers or cessation of work (at least 6 months)|
|Participation Rate||41 subjects with occupational asthma were included in this follow-up study|
|Intervention Effectiveness||Among these 41 subjects, ten were in the same workplace, twenty two had reduced exposure, and nine had ceased to work for at least 6 months before the follow-up examination.
For reduction of exposure (n=22): follow-up vs diagnosis
• Presence of asthma symptoms: 41% vs 95.3%
• PD20FEV1, ug: 374.7 vs 168.5*
For cessation of work (n=9): follow-up vs diagnosis
• Presence of asthma symptoms: 42.6% vs 78.3%
• PD20FEV1, ug: 250.7 vs 173.2**
• Improvement in sputum eosinophilia**
Shorter duration of exposure at diagnosis predicted increase in PD20FEV1 at follow-up (p<0.05).
PD20 ratio (PD20FEV1 methacholine at follow-up and at diagnosis) was 8.1 ± 11.9 and 1.1 ± 0.9 for reduced and continued exposures, respectively, and this difference was statistically significant (p=0.03).