Prevention of Work-related Asthma: Study Search

Prevention LevelSecondary
AuthorDi Giampaolo L
Study Year2012
CountryItaly
Molecular Weight of AgentBoth
Agent CategoryVarious
Specific AgentLatex, manzonia wood, red cedar, cat epithelium, wheat flour
Occupation N/A
Outcome/DiagnosisPulmonary function in allergic occupational asthma (OA) workers
Activity Intervention Exposure cessation or reduction (12 years follow up)
Participation Rate58 subjects participated in the study, all with allergic OA
Intervention Effectiveness30 workers with complete cessation of exposure to the sensitizing allergens (group A): • The median FEV1/h3 x hr decline was significantly greater than predicted value (P<0.05) • The final FEV1 loss was 332.5 ± 108ml 28 workers with reduction in exposure to the sensitizing allergens (group B): • The median FEV1/h3 x hr decline was significantly greater than predicted value (P<0.03) • The FEV1/h3 x hr decline was significantly greater in ex-smoker than non-smoker patients (P<0.03) • There was a significant difference in FEV1/h3/y decay slopes between FEV1 variability >15% and <15% as determined in the first year of observation • The final FEV1 loss was 512.5 ± 180ml There was a significant difference in FEV1 loss between two groups after 4 years from cessation of the exposure. The authors concluded that cessation of workplace allergen exposure was more effective than reduction in limiting pulmonary function decline in workers with OA
Page last reviewed: February 20, 2020