Prevention of Work-related Asthma: Study Search

Prevention LevelSecondary
AuthorTalini D
Study Year2013
Molecular Weight of AgentLMW
Agent CategoryDiisocyanates
Specific AgentToluene diisocyanate (TDI)
Occupation N/A
Outcome/DiagnosisOccupational asthma
Activity Intervention Removal from exposure and reduction in exposure (average follow-up of 11± 3.6 years).
Participation RateForty-six occupational asthma patients participated in the follow-up (participation rate: 56.8%).
Intervention EffectivenessAt the time of follow-up, of the 46 subjects, 32 subjects had been removed from exposure for 6.0 ± 6.9 years, and 14 subjects continued to work with reduced exposure to TDI. 1. For all subjects: a. There was a significant improvement in FEV1 (% Predicted, p<0.05) and the provocative dose of methacholine producing a 20% fall in FEV1 (PD20FEV1) (p<0.01). b. A shorter duration of symptoms before diagnosis was a significant predictor of improvement in PD20FEV1. 2. For 32 subjects removed from exposure: a. The prevalence of the asthma-like symptoms of attacks of shortness of breath, wheeze, and dyspnoea was significantly reduced with p<0.001, p=0.03, and p=0.04, respectively; b. There was a significant improvement in FEV1 and PD20FEV1 only in the group with a higher FEV1 at diagnosis.
Page last reviewed: February 20, 2020